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Renal membrane expression of transporters in diabetic GK rats with vehicle or ipragliflozin. (a and b) Ipragliflozin increased SGLT2 expression in diabetic GK rats, but did not change SGLT1 expression. (c and d) The expression of GLUT2 or AQP1 was not affected by ipragliflozin. Veh: normal diet (CE2, CLEA JAPAN Inc.); Ipra: normal diet containing ipragliflozin [100 mg/kg diet]. Values are expressed as means ± standard error; n = 4–10/group. *p < .05 versus Veh
