Table 1.
Urine and blood parameters after 8‐week treatment of ipragliflozin
| Vehicle | Ipragliflozin | |
|---|---|---|
| Kidney weight (g) | 1.64 ± 0.05 | 1.77 ± 0.07 |
| Urinary protein (mg/day) | 56.5 ± 16.2 | 46.7 ± 8.9 |
| Calculated urine osmolality (mOsmol/kgH2O)a | 1529 ± 146 | 1,259 ± 56* |
| Urinary glucose (mEq/L) | 411 ± 95 | 589 ± 28* |
| Urinary Na+ (mEq/L) | 87 ± 17 | 48 ± 2* |
| Urinary K+ (mEq/L) | 170 ± 27 | 89 ± 6* |
| Urinary Cl− (mEq/L) | 103 ± 18 | 55 ± 2* |
| Urinary Cl− (mEq/day) | 2.3 ± 0.1 | 3.0 ± 0.1* |
| Urinary urea nitrogen (mEq/L) | 682 ± 98 | 398 ± 17* |
| Urinary urea nitrogen (mg/day) | 421 ± 32 | 604 ± 21* |
| Sodium balance (mEq/day) | 1.9 ± 0.6 | 1.9 ± 0.4 |
| Hematocrit (%) | 45.3 ± 0.8 | 47.1 ± 0.4* |
| Blood urea nitrogen (mg/dl) | 19.5 ± 1.4 | 21.4 ± 0.8 |
| Serum creatinine (mg/dl) | 0.25 ± 0.01 | 0.27 ± 0.01* |
| Creatinine clearance (L/day) | 3.8 ± 0.3 | 4.1 ± 0.2 |
| Serum Na+ (mEq/L) | 142 ± 1 | 144 ± 1* |
| Serum Cl− (mEq/L) | 101 ± 2 | 105 ± 1* |
| Serum K+ (mEq/L) | 5.5 ± 0.4 | 5.1 ± 0.1 |
| Fractional excretion of glucose (%) | 16 ± 4 | 46 ± 3* |
| Fractional excretion of Na+ (%) | 0.35 ± 0.03 | 0.44 ± 0.02* |
| Fractional excretion of fluid (%) | 0.8 ± 0.1 | 1.3 ± 0.1* |
a
Calculated formula: 2*[urinary Na+ (mEq/L) + urinary K+ (mEq/L)] + urinary urea nitrogen (mEq/L) + urinary glucose (mEq/L).
*
p < .05 versus Vehicle. Values are means ± SE; n = 4–11/group.