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. 2019 Dec;9(6):545–560. doi: 10.21037/cdt.2019.12.04

Table 2. The potential metabolites PATHWAY of quercetin to AS.

Type No. KEGG pathway Total P value Expected Impact
Positive-ion 1 Primary bile acid biosynthesis 47 0.040875 2.5775 0.23115
2 Starch and sucrose metabolism 50 0.052959 2.742 0.12408
3 Tryptophan metabolism 79 0.064557 4.3324 0.15805
4 Pyrimidine metabolism 60 0.23011 3.2904 0.10265
5 Taurine and hypotaurine metabolism 20 0.30079 1.0968 0.40108
6 Galactose metabolism 41 0.39253 2.2484 0.06409
7 One carbon pool by folate 9 0.39859 0.49356 0.17486
8 Histidine metabolism 44 0.43758 2.413 0.07185
9 Pantothenate and CoA biosynthesis 27 0.44108 1.4807 0.20016
10 beta-Alanine metabolism 28 0.45994 1.5355 0.02328
11 Biotin metabolism 11 0.46299 0.60324 0.19512
12 Vitamin B6 metabolism 32 0.53153 1.7549 0.13073
13 Cyanoamino acid metabolism 16 0.59559 0.87744 0.66667
14 Tyrosine metabolism 76 0.60822 4.1678 0.03828
15 Nitrogen metabolism 39 0.64062 2.1388 0
16 Retinol metabolism 22 0.71247 1.2065 0
17 Phenylalanine, tyrosine and tryptophan biosynthesis 27 0.78376 1.4807 0.0738
18 Arginine and proline metabolism 77 0.80551 4.2227 0.03245
19 Cysteine and methionine metabolism 56 0.82284 3.071 0.02707
20 Lysine biosynthesis 32 0.83747 1.7549 0.02161
21 Terpenoid backbone biosynthesis 33 0.8465 1.8097 0.04799
22 Folate biosynthesis 42 0.90836 2.3033 0.03372
23 Nicotinate and nicotinamide metabolism 44 0.9183 2.413 0
24 Phenylalanine metabolism 45 0.92287 2.4678 0
25 Lysine degradation 47 0.93125 2.5775 0
26 Glycine, serine and threonine metabolism 48 0.93509 2.6323 0.00071
27 Glyoxylate and dicarboxylate metabolism 50 0.94216 2.742 0.01267
28 Steroid hormone biosynthesis 99 0.97666 5.4292 0.00391
29 Drug metabolism-cytochrome P450 86 0.99285 4.7162 0.01613
30 Purine metabolism 92 0.99497 5.0453 0.00158
31 Porphyrin and chlorophyll metabolism 104 0.99752 5.7034 0
Negative-ion 32 Fructose and mannose metabolism 48 0.10721 1.1566 0.09393
33 Folate biosynthesis 42 0.26866 1.012 0.0176
34 Pantothenate and CoA biosynthesis 27 0.48428 0.6506 0
35 Ubiquinone and other terpenoid-quinone biosynthesis 36 0.58713 0.86747 0.01786
36 Nicotinate and nicotinamide metabolism 44 0.66144 1.0602 0.00843
37 Drug metabolism-cytochrome P450 86 0.88188 2.0723 0.03519
38 Amino sugar and nucleotide sugar metabolism 88 0.88771 2.1205 0.00686