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. 2020 Jan 23;12:531–539. doi: 10.2147/CMAR.S232632

Figure 4.

Figure 4

The expression of BRMS1L was regulated by transcription of CBP/p300. (A) CBP/p300 siRNAs were transfected into TE-1D cells and the effective silence of CBP/p300 was determined by qRT-PCR.(B and C) Overexpression of CBP/p300 in ECA-109 was evaluated by qRT-PCRand Western blot. (D) silence of CBP/p300 reduced BRMS1L expression level. (E) Overexpression of CBP/p300 increased BRMS1L expression level. (F and G) Modulation of CBP/p300 influenced BRMS1L promoter activity determined by luciferase reporter assay. (H and I) The correlation between BRMS1L and CBP/p300 mRNA levels were evaluated using the public database. n=3, **P < 0.01, ***P < 0.001, compared to NC/Vector.