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Normal renal cortex and medulla histological features were observed in G1. Black arrows indicate the desquamation of tubular epithelial cells in the cortex and vacuolization in the medulla in G2. A marked amelioration was observed that tetracycline co-treatment alleviated CNP-induced renal histological injury in G3. G1: the sham group; G2: the CNP group; G3: the CNP + tetracycline group. CNP, calcifying nanoparticle.
