Table 2.
Effect Evaluation of Zusanli (ST36) Injection on Improving Nerve Conduction Velocity for Diabetic Peripheral Neuropathy
| Outcomes | Number of trials | Effect estimate MD (95%CI) | p | Study ID |
|---|---|---|---|---|
| 1. ST36 injection of conventional medication versus no intervention | 1 | |||
| 1.1. ST36 injected anisodamine versus no treatment | He (2011)41 | |||
| SNCV in posterior tibial nerve (m/s) | 3.10 (1.86 to 4.34) | <0.01 | ||
| 2. ST36 injection versus intramuscular or intravenous injection of same conventional medication | 4 | |||
| 2.1. ST36 injected mecobalamin versus intravenous injected mecobalamin | Xiao (2007)47 | |||
| NCV in peroneal nerve (m/s) | 5.23 (3.62 to 6.84) | <0.01 | ||
| NCV in tibial nerve (m/s) | 4.97 (2.58 to 7.36) | <0.01 | ||
| 2.2. ST36 injected cobamamide versus intramuscular injected cobamamide | Wang (2013)46 | |||
| MNCV in common peroneal nerve (m/s) | 0.67 (−2.37 to 3.71) | 0.67 | ||
| SNCV in common peroneal nerve (m/s) | 1.43 (−1.41 to 4.27) | 0.32 | ||
| 2.3. ST36 injected cobamamide versus intramuscular injected cobamamide | Zhao (2009)52 | |||
| MNCV in peroneal nerve (m/s) | 4.01 (1.39 to 6.63) | <0.01 | ||
| SNCV in tibial nerve (m/s) | 2.84 (0.46 to 5.22) | 0.02 | ||
| 2.4. ST36 injected mecobalamin versus intramuscular injected mecobalamin | Chen (2012)39 | |||
| SNCV in right superficial peroneal nerve (m/s) | 7.83 (5.02 to 10.64) | <0.01 | ||
| MNCV in left tibial nerve (m/s) | 9.40 (6.19 to 12.61) | <0.01 | ||
| 3. ST36 injection of Chinese herbal extracts with cointervention | 2 | |||
| 3.1. ST36 injected Danshen + intravenous injected thioctic acid versus intravenous injected thioctic acid | Li (2015)42 | |||
| NCV in left median nerve (m/s) | 10.44 (4.86 to 16.02) | <0.01 | ||
| NCV in right median nerve (m/s) | 11.90 (6.10 to 17.70) | <0.01 | ||
| NCV in left common peroneal nerve (m/s) | 6.01 (0.56 to 11.46) | 0.03 | ||
| NCV in right common peroneal nerve (m/s) | 5.89 (0.39 to 11.39) | 0.04 | ||
| 3.2. ST36 injected Danhong+intramuscular injected mecobalamin versus intramuscular injected mecobalamin | Su (2015)44 | |||
| MNCV in median nerve (m/s) | 3.63 (1.94 to 5.32) | <0.01 | ||
| MNCV in common peroneal nerve (m/s) | 4.68 (2.93 to 6.43) | <0.01 | ||
| SNCV in median nerve (m/s) | 3.24 (2.06 to 4.42) | <0.01 | ||
| SNCV in common peroneal nerve (m/s) | 4.45 (2.95 to 5.95) | <0.01 | ||
All randomized controlled trials reported incorporating additional treatments for diabetes such as diet control, exercise, oral insulin, or antidiabetic medications for all treatment groups.
CI, confidence intervals; MD, mean difference; MNCV, motor nerve conduction velocity; NCV, nerve conduction velocity; SNCV, sensory nerve conduction velocity; ST36, Zusanli.