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. 2020 Jan 28;30(1):33–49. doi: 10.1089/nat.2019.0796

Table 5.

Mean (±Standard Deviation) Revusiran-Related Vitamin A and Thyroxine Changes in 6- and 39-Week Toxicity Studies in Monkeys

	6-Week toxicity study
	Males				Females
	Dose (mg/kg)
	0	30	100	300	0	30	100	300
	No. animals/group
	5	5	5	5	5	5	5	5
Vitamin A (μg/mL)	Pre-study (week 2)
	0.58 ± 0.090	0.60 ± 0.105	0.61 ± 0.068	0.61 ± 0.087	0.69 ± 0.172	0.58 ± 0.175	0.54 ± 0.175	0.58 ± 0.214
	Day 6
	0.49 ± 0.085	0.20 ± 0.063^**	0.19 ± 0.028^**	0.18 ± 0.036^**	0.49 ± 0.138	0.22 ± 0.066^***	0.20 ± 0.076^***	0.18 ± 0.044^***
	Day 37
	0.35 ± 0.080	0.07 ± 0.014^**	0.05 ± 0.005^***	0.04 ± 0.005^***	0.38 ± 0.086	0.07 ± 0.018^**	0.06 ± 0.012^***	0.04 ± 0.005^***
	Day 66^a
	0.60	0.24	0.32	0.14	0.67	0.31	0.29	0.16
Thyroxine (μg/dL)	Pre-study (week 2)
	5.7 ± 1.10	5.0 ± 1.16	5.3 ± 0.66	5.4 ± 1.30	5.1 ± 0.43	6.9 ± 1.05	5.6 ± 0.98	5.3 ± 1.22
	Day 6
	5.3 ± 0.97	3.5 ± 0.77^*	5.0 ± 0.78	4.6 ± 1.32	5.0 ± 1.10	5.0 ± 0.70	4.5 ± 0.93	5.1 ± 1.63
	Day 37
	5.3 ± 0.93	2.5 ± 0.78^***	4.1 ± 0.65^*	4.0 ± 0.50^*	4.6 ± 1.47	4.5 ± 1.10	3.6 ± 1.13	3.9 ± 0.87
	Day 66^a
	5.6	4.9	5.7	4.6	4.1	5.4	5.5	5.2

	39-Week toxicity study
	Males				Females
	Dose (mg/kg)
	0	15	75	200	0	15	75	200
	No. animals/group
	6	6	6	6	6	6	6	6
Vitamin A (μg/mL)	Pre-study (week 1)
	0.52 ± 0.288	0.49 ± 0.215	0.51 ± 0.190	0.43 ± 0.205	0.22 ± 0.096	0.26 ± 0.052	0.21 ± 0.048	0.20 ± 0.016
	Day 92
	0.43 ± 0.127	0.09 ± 0.031^**	0.08 ± 0.013^***	0.07 ± 0.012^***	0.47 ± 0.184	0.19 ± 0.115	0.09 ± 0.014^***	0.08 ± 0.012^***
	Day 183
	0.35 ± 0.077	0.05 ± 0.014^***	0.04 ± 0.012^***	0.02 ± 0.004^***	0.30 ± 0.067	0.05 ± 0.018^**	0.02 ± 0.010^***	0.02 ± 0.005^***
	Day 275
	0.31 ± 0.059	0.07 ± 0.016^**	0.05 ± 0.017^***	0.04 ± 0.009^***	0.30 ± 0.092	0.06 ± 0.021^**	0.03 ± 0.010^***	0.02 ± 0.005^***
	Day 366
	0.42 ± 0.051	0.45 ± 0.191	0.38 ± 0.058	0.52 ± 0.049	0.49 ± 0.090	0.52 ± 0.085	0.41 ± 0.070	0.67 ± 0.135
Thyroxine (μg/dL)	Pre-study (week 2)
	5.9 ± 1.23	4.8 ± 1.13	5.5 ± 2.06	4.6 ± 1.46	5.3 ± 0.84	6.7 ± 1.03	6.7 ± 1.43	5.8 ± 0.92
	Pre-study (week 1)
	6.1 ± 1.10	4.9 ± 1.02	5.0 ± 1.34	4.3 ± 0.90	5.7 ± 1.52	6.3 ± 1.21	5.8 ± 0.82	6.1 ± 1.40
	Day 92
	5.8 ± 1.40	4.2 ± 1.23	3.8 ± 1.25^*	3.4 ± 0.74^**	5.5 ± 1.27	4.6 ± 1.05	5.3 ± 3.19	4.4 ± 0.76
	Day 183
	5.2 ± 0.90	3.8 ± 0.88^*	3.2 ± 0.67^**	3.4 ± 0.90^**	4.8 ± 1.07	4.2 ± 0.99	3.9 ± 0.90	4.3 ± 1.16
	Day 275
	5.9 ± 1.01	3.7 ± 1.17^**	3.7 ± 0.62^**	4.7 ± 1.22	6.0 ± 1.28	5.5 ± 1.88	4.5 ± 0.82	4.7 ± 0.93
	Day 366
	5.1 ± 1.63	4.9 ± 0.83	5.0 ± 1.05	5.2 ± 1.12	4.9 ± 1.64	5.3 ± 0.34	5.1 ± 0.43	6.2 ± 0.55

^{^a}

Standard deviation not calculated (n = 2/sex/group).

^{^*}

P ≤ 0.05, ^**P ≤ 0.01, ^***P ≤ 0.001.