Table 1.

Chemical Inhibitors of Endocytic Proteins

Inhibitor	Mechanism of action	Concentration
Filipin	Binds to membrane cholesterol, which destabilizes caveolae	3 μM (2 μg/mL)
Chlorpromazine	Sequesters clathrin and AP2 to intracellular vesicles	25 μM (9 μg/mL)
Amiloride	Inhibits Rac1 and cdc42 by decreasing submembranous pH	100 μM (29 μg/mL)
Dynasore	Noncompetitive inhibitor of dynamin	80 μM (26 μg/mL)
Cytochalasin D	Competitive inhibitor of actin polymerization	10 μM (5 μg/mL)
MβCD	Forms soluble inclusion complexes with membrane cholesterol	5 mM (7 mg/mL)

For general information about inhibitors, see Ivanov [47].

MβCD, methyl-β-cyclodextrin.