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. 2019 Dec 6;245(1):21–33. doi: 10.1177/1535370219892574

Figure 6.

Figure 6.

The uremia toxin increased the expression of VEGF-A, PDGF-BB, FGF-4 and phospho-ERK1/2 (a, b) in ECs and up-regulated proliferation (c) and migration (d, e) of VSMCs, compared to normal serum static group. However, uremia toxin had no notable effects on expression of Caveolin-1 in ECs (a), compared to normal serum static group. Under uremic environment, LSS and OSS showed similar effects on ECs and cocultured VSMCs as in normal growth culture medium (a–e). NSS up-regulated the phosphorylation of ERK1/2, decreased VEGF-A, PDGF-BB in ECs and increased migration of VSMCs (a, b d, e). HSS increased the expression of Caveolin-1, phospho-ERK1/2, decreased the expression of VEGF-A, PDGF-BB, FGF-4 in ECs and down-regulated the migration of cocultured VSMCs (a, b d, e). However, both NSS and HSS had no effect on proliferation (c) in VSMCs. Values were expressed as mean ± SD for each condition from four independent experiments (#P < 0.05 compared to the normal serum static group; *P < 0.05 compared to the uremic static group; **P < 0.001 compared to the uremic static group). (A color version of this figure is available in the online journal.)