Table 2.
Volumes of cortical and subcortical brain structures.
| Structure | Raw volumes in ml (SD) |
Intracranial volume corrected |
||||||
|---|---|---|---|---|---|---|---|---|
| All | Females | Males | Sex | Age | Sex × age | Age2 | Sex × age2 | |
| N = 442 | N = 223 | N = 219 | p-Values | p-Values | p-Values | p-Values | p-Values | |
| Accumbens | 1.35 (0.21) | 1.28 (0.19) | 1.41 (0.21) | ns | ns | ns | ns | ns |
| Amygdala | 3.43 (0.38) | 3.25 (0.32) | 3.61 (0.35) | 0.023 | ns | ns | ns | ns |
| Caudate | 8.09 (1.06) | 7.71 (1.01) | 8.48 (0.97) | ns | ns | ns | ns | ns |
| Hippocampus | 9.2 (0.91) | 8.78 (0.78) | 9.62 (0.82) | ns | ns | ns | ns | ns |
| Pallidum | 3.65 (0.40) | 3.45 (0.33) | 3.85 (0.36) | ns | ns | ns | ns | ns |
| Putamen | 11.89 (1.34) | 11.26 (1.21) | 12.53 (1.14) | ns | <0.001a | ns | <0.001a | ns |
| Thalamus | 14.95 (1.44) | 14.25 (1.26) | 15.66 (1.25) | 0.045 | <0.001a | ns | <0.001a | ns |
| Lateral Ventricle | 11.95 (6.66) | 11.11 (6.26) | 12.81 (6.94) | ns | <0.001a | ns | <0.001a | ns |
| 3rd ventricle | 0.85 (0.21) | 0.8 (0.16) | 0.9 (0.23) | ns | <0.001a | 0.028 | <0.001a | 0.016 |
| 4th ventricle | 1.94 (0.58) | 1.82 (0.58) | 2.06 (0.56) | ns | ns | ns | ns | ns |
| Cerebellum GM | 89.55 (11.81) | 83.88 (10.24) | 95.33 (10.43) | 0.008 | <0.001a | ns | <0.001a | ns |
| Cerebellum WM | 31.29 (4.32) | 30.11 (4.06) | 32.5 (4.24) | ns | <0.001a | ns | <0.001a | ns |
| Cerebral GM | 741.93 (72.95) | 700.96 (59.26) | 783.64 (61.03) | <0.001a | <0.001a | <0.001a | <0.001a | <0.001a |
| Cerebral WM | 489.95 (55.61) | 461.16 (44.96) | 519.26 (49.86) | 0.002 | <0.001a | 0.013 | <0.001a | 0.022 |
| Total brain | 1231.88 (117.81) | 1162.12 (92.02) | 1302.9 (97.00) | <0.001a | 0.002 | ns | <0.001a | ns |
| Intracranium | 1573.02 (184.05) | 1464.54 (154.30) | 1683.48 (141.33) | <0.001a | ns | 0.001 | 0.045 | <0.001a |
| Frontal GM | 187.78 (21.01) | 177.27 (17.88) | 198.49 (18.43) | <0.001a | <0.001a | 0.001 | <0.001a | 0.001 |
| Parietal GM | 136.5 (16.75) | 128.96 (14.42) | 144.18 (15.44) | <0.001a | <0.001a | 0.001 | <0.001a | <0.001a |
| Temporal GM | 133.6 (15.31) | 125.88 (12.91) | 141.46 (13.47) | 0.002 | <0.001a | 0.018 | <0.001a | 0.016 |
| Occipital GM | 50.84 (6.72) | 47.98 (5.88) | 53.75 (6.27) | 0.002 | <0.001a | 0.014 | <0.001a | 0.014 |
| ACC GM | 24.56 (3.24) | 23.27 (2.85) | 25.88 (3.07) | 0.034 | <0.001a | ns | <0.001a | ns |
Abbreviations: GM, gray matter; WM, white matter; ACC, anterior cingulate cortex; ns, not significant.
Bonferroni p-Value = 0.002.
a
Survives Bonferroni correction.