Table 5. Association between indicators of log-transformed local fat deposits and lung function.
| Variable | FEV1% predicted* | FVC% predicted* | FEV1/FVC (%)† |
|---|---|---|---|
| Male (n=282) | |||
| PF (cm3) | −2.504±4.814 (0.603) | −5.093±3.991 (0.203) | 0.646±2.234 (0.773) |
| ITF (cm3) | −9.011±4.006 (0.025)‡ | −8.882±3.317 (0.008) | −2.158±1.859 (0.247)‡ |
| STF (cm3) | −13.119±5.544 (0.019) | −9.303±4.620 (0.045) | −6.578±2.442 (0.008)‡ |
| VAF (cm3) | −8.795±3.383 (0.010)‡ | −7.355±2.811 (0.009) | −3.850±1.533 (0.013)‡ |
| SAF (cm3) | −6.520±4.100 (0.113) | −2.299±3.420 (0.502) | −6.678±1.765 (0.001)‡ |
| Female (n=173) | |||
| PF (cm3) | 0.042±6.913 (0.995) | −3.134±6.064 (0.606) | 0.048±2.635 (0.985) |
| ITF (cm3) | 0.600±5.823 (0.918) ‡ | −3.409±5.106 (0.505) | 1.550±2.208 (0.483)‡ |
| STF (cm3) | −16.418±7.527 (0.031) | −17.583±6.563 (0.008) | −0.072±2.725 (0.979)‡ |
| VAF (cm3) | 6.424±0.117 (0.162) ‡ | 2.320±4.034 (0.566) | 2.667±1.735 (0.126)‡ |
| SAF (cm3) | −4.487±5.550 (0.420) | −9.776±4.823 (0.044) | 2.411±1.980 (0.225)‡ |
Each association between fat volumes and lung function were evaluated in a separate multiple regression analysis. Log-transformed fat volumes were used. Data presented as regression coefficients ± standard error (P value). *Adjusted for pack-years of smoking, HDL, and hsCRP. †Adjusted for age, height, pack-years of smoking, HDL, and hsCRP. ‡P value for the interaction of sex to the association (Pinteraction <0.05). HDL, high-density lipoprotein; hsCRP, high sensitivity C-reactive protein; PF, pericardial fat; ITF, intra-thoracic fat; TF, total thoracic fat; STF, subcutaneous thoracic fat; VAF, visceral abdominal fat; SAF, subcutaneous abdominal fat; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.