Table 3. Univariate COX analysis of overall survival in surgical stage IV patients.
| Variables | Univariate analysis | ||
|---|---|---|---|
| HR | 95% CI | P value | |
| Female (vs. male) | 0.314 | 0.148–0.662 | 0.001 |
| Age ≥60 years (vs. <60) | 2.668 | 1.423–5.001 | 0.001 |
| Non-smoker (vs. smoker) | 0.398 | 0.212–0.747 | 0.003 |
| CCI score 2–3 (vs. 0–1) | 1.967 | 0.604–6.410 | 0.252 |
| Non-SCC (vs. SCC) | 0.293 | 0.138–0.624 | 0.001 |
| cT 3–4 (vs. T1–2) | 2.478 | 1.331–4.614 | 0.003 |
| cN 2–3 (vs. N0–1) | 1.143 | 0.588–2.220 | 0.197 |
| Sites of metastasis | 0.008 | ||
| Pleural metastases | Ref | 1 | |
| 1–3 brain metastases | 1.014 | 0.381–2.704 | 0.977 |
| 1–3 metastases in 1 extra-brain organ | 2.959 | 1.390–6.297 | 0.005 |
| Multiple metastases | 2.721 | 1.015–7.293 | 0.047 |
| Pulmonary resection | 0.738 | ||
| Lobectomy | Ref | 1 | |
| Sublobar resection | 0.878 | 0.208–3.709 | 0.859 |
| Pneumonectomy | 1.280 | 0.653–2.508 | 0.473 |
| Pulmonary margin R1 (vs. R0) | 6.046 | 1.389–26.314 | 0.006 |
| No treatment for metastases | 2.074 | 1.089–3.950 | 0.014 |
| Adjuvant treatment | <0.001 | ||
| Chemotherapy | Ref | 1 | |
| TKI or TKI + chemotherapy | 0.211 | 0.083–0.534 | 0.001 |
| No treatment | 4.822 | 2.032–11.443 | <0.001 |
| Unknown | 0.730 | 0.305–1.748 | 0.480 |
HR, hazard ratio; CI, confidence interval; CCI, Charlson comorbidity index; SCC, squamous cell carcinoma; TKI, tyrosine kinase inhibitor.