Table 4. Multivariate COX analysis of overall survival in surgical stage IV patients.
| Variables | Multivariate analysis | ||
|---|---|---|---|
| HR | 95% CI | P value | |
| Age ≥60 (vs. <60) | 2.302 | 1.154–4.593 | 0.018 |
| cT 3–4 (vs. cT1–2) | 2.969 | 1.396–6.313 | 0.005 |
| Sites of metastasis | |||
| Pleural metastases | Ref | 1 | |
| 1–3 brain metastases | 1.812 | 0.617–5.321 | 0.279 |
| 1–3 metastases in 1 extra-brain organ | 2.572 | 1.130–5.852 | 0.024 |
| Multiple metastases | 3.603 | 1.195–10.861 | 0.023 |
| Adjuvant treatment | |||
| Chemotherapy | Ref | 1 | |
| TKI or TKI + chemotherapy | 0.293 | 0.109–0.784 | 0.015 |
| No treatment | 5.781 | 2.135–15.650 | 0.001 |
| Unknown | 1.158 | 0.434–1.396 | 0.770 |
HR, hazard ratio; CI, confidence interval; TKI, tyrosine kinase inhibitor.