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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Oncogene. 2019 Aug 12;38(42):6818–6834. doi: 10.1038/s41388-019-0925-0

Fig. 2.

Fig. 2

Functional enrichment in the 3D fibrin gels culture and regulatory networks for membrane. (A) Top 30 significantly enriched terms (p <1.0E-4) in Gene Ontology and KEGG pathway for DEGs. Terms in red font are related to mechanotransduction or cancer proliferation. EnrichRatio: The ratio of enriched genes in the term. FDR: false discovery rate. CC: cellular component. BP: biological process. MF: molecular function. (B) Heatmap of 25 differentially expressed membrane protein genes. (C) TF and miRNA regulatory network for membrane proteins. Red and green nodes represent up and down regulations in comparison of 3day versus 12h. Round nodes are genes, triangle nodes are TFs, and square nodes are miRNAs. Red edge represents miRNA regulation and purple edge indicates TF regulation. Gray edge represents membrane protein regulation.