REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
APC anti-human sequestosome (SQSTM1; p62)	Abcam	Cat# Ab194721; RRID:AB_2728795
PE anti-human ⍺-smooth muscle actin ⍺-SMA clone 1A4	R and D Systems	Cat# IC1420P; RRID:AB_2223026
APC anti-human Intercellular Adhesion Molecule 1 (ICAM-1) clone HA58	eBioscience	Cat# 17-0549-41; RRID:AB_10718240
BUV805 anti-human CD45 clone HI30	BD biosciences	Cat# 564914; RRID:AB_2744401
BV711 anti-human CD3 clone OKT3	BioLegend	Cat# 317328; RRID:AB_2562907
BUV395 anti-human CD3 clone UCHT1	BD biosciences	Cat# 563546; RRID:AB_2744387
BV605 anti-human CD3 clone OKT3	BioLegend	Cat# 317322; RRID:AB_2561911
BUV395 anti-human CD4 clone SK3	BD biosciences	Cat# 563550; RRID:AB_2738273
APC-Cy7 anti-human CD4 clone RPA-T4	BioLegend	Cat# 300518; RRID:AB_314086
Pe-Cy7 anti-human CD4 clone OKT4	BioLegend	Cat# 317414; RRID:AB_571959
PerCP anti-human CD4 clone RMA4-5	BioLegend	Cat# 100538; RRID:AB_893325
Alexa Fluor700 anti-human CD8⍺ clone RPA-T8	BioLegend	Cat# 301028; RRID:AB_493745
PerCp-Cy5.5 anti-human CD8⍺ clone RPA-T8	BioLegend	Cat# 301032; RRID:AB_893422
BV786 anti-human CD8⍺ clone RPA-T8	BioLegend	Cat# 301046; RRID:AB_2563264
PE anti-human CD161 clone 191B8	Miltenyi Biotec	Cat# 130-092-677; RRID:AB_871632
PerCP-Cy5.5 anti-human pan ⍺β-TCR clone IP26	BioLegend	Cat# 306724; RRID:AB_2563002
APC anti-human pan ɣδ-TCR clone B3	BioLegend	Cat# 331212; RRID:AB_1089214
BV785 anti-human Va7.2 TCR clone 3C10	BioLegend	Cat# 351722, RRID:AB_2566042
BV510 anti-human CD19 clone SJ25C1	BD biosciences	Cat# 562947; RRID:AB_2737912
Pe-Cy7 anti-human CD56 clone NCAM16.2	BD biosciences	Cat# 335791; RRID:AB_399970
BV421 anti-human CD28 clone CD28.2	BioLegend	Cat# 302929; RRID:AB_2561341
Pe/Dazzle594 anti-human CD69 clone FN50	BioLegend	Cat# 310942; RRID:AB_2564277
BV605 anti-human CD69 clone FN50	BioLegend	Cat# 310938, RRID:AB_2562307
BV711 anti-human CD103 clone Ber-ACT8	BioLegend	Cat# 350222; RRID:AB_2629651
BV605 anti-human CD103 clone Ber-ACT8	BioLegend	Cat# 350218; RRID:AB_2564283
BV421 anti-human CXCR6 (CD186) clone K041E5	BioLegend	Cat# 356014; RRID:AB_2563873
APC anti-human CXCR6 (CD186) clone K041E5	BioLegend	Cat# 356006; RRID:AB_2562223
Pe-Cy7 anti-human CCR7 (CD197) clone 3D12	BD biosciences	Cat# 557648; RRID:AB_396765
Alexa Fluor700 anti-human CD45RA clone HI100	BD biosciences	Cat# 560673; RRID:AB_1727496
V450 anti-human Interferon-gamma (IFNɣ) clone B27	BD biosciences	Cat# 560371; RRID:AB_1645594
Alexa Fluor700 anti-human Granzyme B clone GB11	BD biosciences	Cat# 560213; RRID:AB_1645453
BV510 anti-human Perforin clone dG9	BioLegend	Cat# 308120; RRID:AB_2563829
PE-Cy7 anti-human Ki67 clone 20Raj1	eBioscience	Cat# 25-5699-42; RRID:AB_2573462
BV605 anti-human CD38 clone HIT2	BioLegend	Cat# 303532; RRID:AB_2562915
BV510 anti-human CD127 (IL7Rα) clone A019D5	BioLegend	Cat# 351331; RRID:AB_2561935
PE anti-human PD-1 (CD279) clone EH12.2h7	BioLegend	Cat# 329906; RRID:AB_940483
anti-human CD28 unconjugated clone CD28.2	Thermo Fisher Scientific	Cat# 16-0289-85; RRID:AB_468927
anti-human CD23 unconjugated clone OKT3	Thermo Fisher Scientific	Cat# 16-0037-85, RRID:AB_468855
Anti-human IL15 (blocking Antibody)	R&D systems	Cat# MAB247; RRID:AB_212457
Biological Samples
Healthy human peripheral blood mononuclear cells	This paper	N/A
Intrahepatic lymphocytes isolated from perfusion fluid and explanted human liver tissue	This paper	N/A
Primary human hepatic stellate cells (HSCs)	This paper	N/A
Chemicals, Peptides, and Recombinant Proteins
Ficoll-Paque PLUS density gradient media	GE Healthcare	Cat# 17144003
Pancoll Lymphocyte Separating Medium, human	Pan Biotech	Cat# P04-60125
Percoll density gradient media	GE Healthcare	Cat# 17089101
RPMI1640	Thermo Fisher Scientific	Cat# 21875
Collagenase IV	Thermo Fisher Scientific	Cat# 17104-019
DNase I	Roche	Cat# 11284932001
FBS	Sigma-Aldrich	Cat# F7524
Penicillin-streptomycin	Thermo Fisher Scientific	Cat# 15140122
Phosphate buffered saline	Thermo Fisher Scientific	Cat# 14190
Fixable live/dead Near-Infrared	Thermo Fisher Scientific	Cat# L10119
Fixable live/dead Violet	Thermo Fisher Scientific	Cat# L34955
Fixable live/dead Blue	Thermo Fisher Scientific	Cat# L23105
Brilliant Stain buffer	BD biosciences	Cat# 563794
Formaldehyde solution	Sigma-Aldrich	Cat# F8775
10X perm buffer	eBioscience	Cat# 00-5523-00
Brefeldin A	Sigma-Aldrich	Cat# B6542
Foxp3 / Transcription Factor staining buffer kit	eBioscience	Cat# 00-5523-00
ArC amine reactive compensation bead kit	Thermo Fisher Scientific	Cat# A10346
Bafilomycin A1	Sigma-Aldrich	Cat# B1793
Anti-mouse Ig compensation particle set	BD biosciences	Cat# 552843
RPMI1640 phenol-red free	Thermo Fisher Scientific	Cat# 11853-063
MRT68921 dihydrochloride	Sigma-Aldrich	Cat# SML1644 Petherick et al., 2015
3-Methyladenine	Sigma-Aldrich	Cat# M9281 Wu et al., 2010
MitoTEMPO	Sigma-Aldrich	Cat# SML0737 Fisicaro et al., 2017
N-acetyl-L-cysteine	Sigma-Aldrich	Cat# A9165
MitoTracker Deep Red FM	Thermo Fisher Scientific	Cat# M22426
MitoTracker Green FM	Thermo Fisher Scientific	Cat# M7514
Dimethyl sulfoxide	Sigma-Aldrich	Cat# D4540
Verapamil hydrochloride	Sigma-Aldrich	Cat# V4629
Cyclosporin A	Sigma-Aldrich	Cat# 30024
CellTrace violet	Thermo Fisher Scientific	Cat# C34557
MHC class I dextramers	Immudex	-
recombinant human IL-2	Peprotech	Cat# 200-02
recombinant human IL-15	R and D Systems	Cat# 247-ILB-005/CF
recombinant human TGFβ	BioLegend	Cat# 580702
Optiprep Density Gradient Medium	Sigma-Aldrich	Cat# D1556
Stellate Cell Medium	ScienCell Research Laboratories	Cat# 5301
Trypsin-EDTA (0.05%) phenol red	Thermo Fisher Scientific	Cat# 25300054
Recombinant human IL15-Rα-FC chimera protein	R and D Systems	Cat# 147-IR-100
Critical Commercial Assays
FlowCellect Autophagy LC3 Antibody-based Assay Kit (LC3 clone 4E12)	Merck-millipore (now Luminex)	Cat# FCCH100171 Eng et al., 2010
Cyto-ID	Enzo LifeSciences	Cat# ENZ-51031-0050
panT cell isolation kit, human	Miltenyi Biotec	130-096-535
Software and Algorithms
Prism version 7.0e	GraphPad	RRID:SCR_002798; https://www.graphpad.com/
FlowJo version 10.4.1 for mac	Tree Star	RRID:SCR_008520; https://www.flowjo.com
INSPIRE and IDEAS software	Merck-millipore (now Luminex)	-
R version 3.2.4	www.r-project.org	RRID:SCR_001905; http://www.rproject.org/
Other
GentleMACS dissociator	Miltenyi Biotec	Cat# 130-093-235
LSRII Fortessa X20 cell analyzer	BD biosciences	-
LSRII cell analyzer	BD biosciences	-
Amnis ImageStreamX imaging flow cytometer	Merck-millipore (now Luminex)	-