Table 1.
Final clinical practice guidelines consensus statements on maintenance therapy after high dose therapy and autologous hematopoietic cell transplantation for Hodgkin lymphoma
| Consensus Statements - Hodgkin Lymphoma | Grading of Recommendations† | Percentage of Panelists in Agreement |
|---|---|---|
| 1. The panel recommends post autologous HCT consolidation/maintenance with BV for 16 cycles in BV-naïve classic Hodgkin lymphoma (HL) with at least one or more high-risk features as defined by the AETHERA study.** | A | 92% |
| 2. The panel does not recommend post-autologous HCT consolidation/maintenance with BV for HL with prior evidence of disease refractory to BV. | C | 96% |
| 3. The recommended duration of post-auto-HCT BV consolidation/maintenance therapy is for a maximum of 16 cycles every 3 weeks as described in AETHERA trial, or until unacceptable toxicity or disease relapse/progression (whichever occurs first).** | A | 100% |
| 4. The panel recommends post autologous HCT consolidation/maintenance with BV in HL with one or more high-risk features as defined by the AETHERA trial and limited prior exposure to BV (~4–6 cycles) preceding the autologous HCT, but without any evidence of BV refractory disease. | C | 100% |
| 5. Sufficient data do not exist to use the pre-autologous-HCT PET (or PET/CT) scan status to guide the use of post autologous HCT consolidation/maintenance therapy with BV for HL with one or more high-risk features as defined by AETHERA Trial. | C | 84% |
Abbreviation: HCT – hematopoietic cell transplantation; BV – brentuximab vedontin; PET/CT – positron emission tomography/computed tomography
Consensus statement based on observed PFS benefit, but no OS benefit in randomized trials
Agency of Healthcare Research and Quality (AHRQ) grading of recommendations based on level of evidence13:
A = There is good research-based evidence to support the recommendation;
B = There is fair research-based evidence to support the recommendation;
C = The recommendation is based on expert opinion and panel consensus:
X = There is evidence of harm from this intervention.