Table 4.
Percentage Differences in hs‐cTnT, NT‐proBNP, and hsCRP Between Levels of Alcohol Use
| Alcohol Use | % Difference (95% CI), Adjusted for Age and Sex | % Difference (95% CI), Additionally Adjusted for Smoking and Education | % Difference (95% CI), Additionally Adjusted for Mediatorsa |
|---|---|---|---|
| hs‐cTnT (n=2595) | |||
| Narcology clinic subsample | 6.6 (0.7 to 12.8) | 10.3 (3.7 to 17.4) | 10.3 (3.7 to 17.3) |
| Harmful drinkers, general population sample | −14.4 (−22.6 to −5.3) | −11.5 (−20.1 to −2) | −9.6 (−18.2 to −0.1) |
| Hazardous drinkers, general population sample | −3.3 (−7.7 to 1.4) | −2.6 (−7.1 to 2.1) | −1.8 (−6.3 to 2.8) |
| Nonproblem drinking, general population sample | 0 (Reference group) | 0 (Reference group) | 0 (Reference group) |
| Nondrinkers, general population sample | 2.1 (−3.6 to 8.2) | 1.6 (−4.1 to 7.7) | −0.6 (−6.1 to 5.1) |
| P value for linear trend (among drinkers) | 0.272 | 0.068 | 0.047 |
| P value for heterogeneity | <0.001 | <0.001 | <0.001 |
| NT‐proBNP (n=2595) | |||
| Narcology clinic subsample | 68.6 (47.6 to 92.6) | 46.7 (26.8 to 69.8) | 34.9 (17.1 to 55.4) |
| Harmful drinkers, general population sample | 45.6 (14.9 to 84.6) | 31.5 (3.4 to 67.2) | 30.1 (3.5 to 63.5) |
| Hazardous drinkers, general population sample | 1.5 (−9.1 to 13.3) | −3.5 (−13.7 to 7.8) | 1.9 (−8.4 to 13.3) |
| Nonproblem drinking, general population sample | 0 (Reference group) | 0 (Reference group) | 0 (Reference group) |
| Nondrinkers, general population sample | 10.3 (−3.7 to 26.4) | 6.6 (−6.9 to 22.1) | 0.9 (−11.3 to 14.8) |
| P value for linear trend (among drinkers) | <0.001 | <0.001 | <0.001 |
| P value for heterogeneity | <0.001 | <0.001 | <0.001 |
| hsCRP (n=2562) | |||
| Narcology clinic subsample | 117.1 (86.1 to 153.2) | 69.2 (43 to 100.2) | 99.7 (70.9 to 133.4) |
| Harmful drinkers, general population sample | 33.9 (2.2 to 75.4) | 13.4 (−13.7 to 49) | 28.4 (0.2 to 64.6) |
| Hazardous drinkers, general population sample | 14.7 (1.1 to 30.2) | 6.9 (−5.8 to 21.4) | 0.5 (−10.5 to 12.9) |
| Nonproblem drinking, general population sample | 0 (Reference group) | 0 (Reference group) | 0 (Reference group) |
| Nondrinkers, general population sample | −9 (−22.1 to 6.4) | −12.2 (−24.8 to 2.5) | −10.7 (−22.4 to 2.8) |
| P value for linear trend (among drinkers) | <0.001 | <0.001 | <0.001 |
| P value for heterogeneity | <0.001 | <0.001 | <0.001 |
Dependent variable was ln transformed, and the regression coefficients were back transformed and presented as percentage difference in mean in comparison to the reference group. hsCRP indicates high‐sensitivity C‐reactive protein; hs‐cTnT, high‐sensitivity cardiac troponin T; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide.
Possible mediators included were systolic and diastolic blood pressure, use of blood pressure medication, lipid profile (total cholesterol, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, apolipoprotein A1, and apolipoprotein B), renal function (estimated glomerular filtration rate), body mass index, and waist/hip ratio.