. 2019 Dec 24;9(1):e013841. doi: 10.1161/JAHA.119.013841

Table 1.

Ancillary Analysis Results for Odds of CSVD, Stratified by BPV Metric, BP Measurement, and CSVD Assessment

BP Measure	Type of BPV Metric	No. of Studies^References	OR	95% CI	I²
Systolic	SD	627, 57, 83, 88, 89, 90	1.28^a	1.19–1.39^a	0
	Weighted SD	289, 90	1.75^a	1.38–2.22^a	0
	Coefficient of variation	627, 58, 86, 88, 89, 90	1.36^a	1.12–1.67^a	88
	Variance independent of the mean	188	1.23	1.05–1.44	···
	Successive variation	188	1.00	0.91–1.10	···
	Average real variability	282, 89	1.18 ^a	1.03–1.35^a	2
	Variance in residuals	281, 84	1.36	0.66–2.79	71
	Oscillometric	1027, 57, 58, 82, 83, 85, 86, 87, 89, 90	1.29^a	1.13–1.48^a	88
	Auscultatory	381, 84, 88	1.18	0.95–1.46	62
	Day^b	427, 82, 83, 90	1.25^a	1.08–1.46^a	72
	Night^b	427, 82, 83, 90	1.19^a	1.05–1.34^a	63
	24‐h ABPM	727, 57, 82, 83, 86, 89, 90	1.26^a	1.09–1.47^a	82
	HBPM and visit to visit	658, 81, 84, 85, 87, 88	1.27^a	1.11–1.45^a	70
	Visit‐to‐visit BP interval <6 mo	287, 88	1.24^a	1.06–1.44^a	0
	Visit‐to‐visit BP interval >6 mo	358, 81, 84	1.21	0.96–1.51	71
	MRI only	1327, 57, 58, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90	1.27^a	1.14–1.42^a	85
	CT with or without MRI	···	···	···	···
	Primarily Asian	727, 57, 62, 81, 88, 89, 90	1.42^a	1.27–1.58^a	36
	Non‐Asian	658, 82, 84, 86, 87, 97	1.13 ^a	1.02–1.26^a	73
Diastolic	SD	288, 89	1.24^a	1.03–1.50^a	0
	Weighted SD	189	1.97	1.06–3.66	···
	Coefficient of variation	427, 58, 88, 89	1.33^a	1.10–1.60^a	63
	Variance independent of the mean	188	1.20	0.98–1.47	···
	Successive variation	188	1.08	0.95–1.23	···
	Average real variability	189	1.56	0.89–2.73
	Variance in residuals	···	···	···	···
	Day^b	227, 90	1.46^a	1.23–1.74^a	0
	Night^b	227, 90	1.27^a	1.11–1.47^a	23
	Oscillometric	427, 58, 87, 89	1.56^a	1.19–2.04^a	56
	Auscultatory	284, 88	1.15	1.05–1.27	0
	24‐h ABPM	227, 89	1.86 ^a	1.36–2.55^a	0
	HBPM and visit to visit	458, 84, 87, 88	1.22^a	1.14–1.31^a	13
	Visit‐to‐visit BP interval <6 mo	287, 88	1.35	0.95–1.92	48
	Visit‐to‐visit BP interval >6 mo	258, 84	1.19^a	1.09–1.29^a	15
	MRI only	627, 58, 84, 87, 88, 89	1.30^a	1.14–1.48^a	53
	CT with or without MRI	···	···	···	···
	Primarily Asian	327, 88, 89	1.53 ^a	1.08–2.16^a	63
	Non‐Asian	358, 84, 87	1.21^a	1.08–1.37^a	42

ABPM indicates ambulatory BP monitoring; BP, blood pressure; BPV, BP variability; CSVD, cerebral small‐vessel disease; CT, computed tomography; HBPM, home BP monitoring; MRI, magnetic resonance imaging; OR, odds ratio.

Significant values (when ≥2 studies).

Any metric of BPV recorded from ABPM and subdivided by day and night measures.