Skip to main content
. 2019 Dec 24;9(1):e014358. doi: 10.1161/JAHA.119.014358

Figure 1.

Figure 1

PCSK9Qβ‐003 vaccine decreased serum TC and LDL‐C in the UUO model. A, Process of animal experiments in the LDLR +/− mice+UUO. B, The vaccine was analyzed on a SDS‐PAGE gel. The figure showed the PCSK9 peptide conjugated to the Qβ virus‐like particles. C, The LDLR +/− mice were immunized subcutaneously, and the anti‐PCSK9Qβ‐003 titers were measured by ELISA. D through F, TC, LDLC and TG was decreased in the PCSK9Qβ‐003 vaccine group compared with the other groups. G, The total PCSK9 level was significantly elevated in the PCSK9Qβ‐003 vaccine group compared with the other groups. n=6 per group. Data are expressed as means±SEM. & P<0.05 vs the Sham group; # P<0.05 vs the PBS group; *P<0.05 vs the Qβ virus‐like particles group. LDL‐C indicates low‐density lipoprotein cholesterol; PBS, the phosphate‐buffered saline group; PCSK9, proprotein convertase subtilisin/kexin type 9; PCSK9Qβ‐003, the PCSK9Qβ‐003 vaccine group; Sham, the sham group; TC, total cholesterol; TG, triglyceride; UUO, unilateral ureteral obstruction; VLP, the Qβ virus‐like particles group.