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. 2020 Jan 4;9(1):e013452. doi: 10.1161/JAHA.119.013452

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© 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Human Cardio Chimeras (hCCs) exhibit variable expression level of cardiomyogenic commitment markers. mRNA expression level of (A) GATA4 (GATA binding protein), (B) TNNT2 (cardiac type troponin T2), (C) PECAM1 (platelet and endothelial cell adhesion molecule 1), and (D) smooth muscle actin (SMA) for parent cells and hCCs. N=3 independent experiments, 3 replicates (wells) per group per experiment. All genes expression is normalized to ribosomal 18s and represented as a fold change relative to mesenchymal stem cells (MSCs). Statistical analysis was performed by 1‐way ANOVA multiple comparison with Dunnett. *P<0.05 vs c‐kit⁺ cardiac interstitial cell (cCIC), **P<0.001 vs cCIC, ***P<0.0001 vs cCIC, ^$ P<0.05 vs MSC, ^$$ P<0.001 vs MSC, ^$$$ P<0.0001 vs MSC. Error bars are ±SEM.