Table 3.
Number of patients with ≥10-point score deterioration and improvement in HR-QOL from baseline in each category of NCF by using three cut-off values at 4 months
| n (%: n/No. of patient category) | p-value | p-value | ||||
|---|---|---|---|---|---|---|
| DETERIORATION | Improvement | Stable | Deterioration | Both | Deterioration vs. others | Deterioration/Both vs. others |
| QLQ-C30: | ||||||
| Global Health Status | ||||||
| 1.0 SD | 2 (33) | 2 (40) | 4 (24) | 4 (31) | 0.729 | 0.701 |
| 1.5 SD | 2 (25) | 4 (44) | 3 (20) | 3 (33) | 0.480 | 0.507 |
| 2.0 SD | 1 (14) | 6 (40) | 3 (20) | 2 (50) | 0.480 | 0.744 |
| Functional scales | ||||||
| 1.0 SD | 1 (17) | 1 (20) | 9 (53) | 1 (8) | 0.013* | 0.457 |
| 1.5 SD | 1 (13) | 2 (22) | 8 (53) | 1 (11) | 0.015* | 0.296 |
| 2.0 SD | 1 (14) | 3 (20) | 7 (47) | 1 (25) | 0.083 | 0.168 |
| Symptom scales | ||||||
| 1.0 SD | 2 (33) | 1 (20) | 8 (47) | 4 (31) | 0.328 | 0.716 |
| 1.5 SD | 2 (25) | 3 (33) | 7 (47) | 3 (33) | 0.336 | 0.519 |
| 2.0 SD | 2 (29) | 6 (40) | 6 (40) | 1 (25) | 0.749 | 1.000 |
| QLQ-BN20: | ||||||
| 1.0 SD | 2 (33) | 0 (0) | 8 (47) | 5 (39) | 0.328 | 0.168 |
| 1.5 SD | 2 (25) | 2 (22) | 7 (47) | 4 (44) | 0.336 | 0.195 |
| 2.0 SD | 2 (29) | 4 (27) | 7 (47) | 2 (50) | 0.336 | 0.211 |
| IMPROVEMENT | Improvement | Stable | Deterioration | Both | Improvement vs. others | Improvement/Both vs. others |
| QLQ-C30: | ||||||
| Global Health Status | ||||||
| 1.0 SD | 3 (50) | 1 (20) | 1 (20) | 5 (39) | 0.393 | 0.346 |
| 1.5 SD | 3 (38) | 2 (22) | 2 (22) | 5 (56) | 1.000 | 0.189 |
| 2.0 SD | 3 (43) | 4 (27) | 4 (27) | 2 (50) | 0.673 | 0.463 |
| Functional scales | ||||||
| 1.0 SD | 4 (67) | 1 (20) | 1 (20) | 4 (31) | 0.168 | 0.533 |
| 1.5 SD | 5 (63) | 3 (33) | 3 (33) | 2 (22) | 0.117 | 0.745 |
| 2.0 SD | 4 (57) | 5 (33) | 5 (33) | 1 (25) | 0.390 | 0.491 |
| Symptom scales | ||||||
| 1.0 SD | 2 (33) | 1 (20) | 1 (20) | 3 (23) | 0.651 | 1.000 |
| 1.5 SD | 3 (38) | 3 (33) | 3 (33) | 2 (22) | 0.658 | 1.000 |
| 2.0 SD | 2 (29) | 4 (27) | 4 (27) | 1 (25) | 1.000 | 1.000 |
| QLQ-BN20: | ||||||
| 1.0 SD | 3 (50) | 1 (20) | 1 (20) | 1 (8) | 0.077 | 1.000 |
| 1.5 SD | 4 (50) | 1 (11) | 1 (11) | 0 (0) | 0.033* | 0.698 |
| 2.0 SD | 2 (29) | 3 (20) | 3 (20) | 0 (0) | 0.606 | 1.000 |
*p-value < 0.05
Both significant improvement and deterioration were observed in different NCF domains HR-QOL health-related quality of life, NCF neurocognitive function. QLQ-C30 European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30. QLQ-BN20 European Organization for Research and Treatment of Cancer (EORTC) Brain Cancer Module