Table 1.

The genes with high frequency in 13 “sKLD-signaling genes” groups in the critical stage (stage IIA) for LUSC

Gene	Frequency	Location	Family*	Relation with cancer progression
BIRC5	13	Cytoplasm	other	The miR-195 axis regulates lung squamous cell carcinoma (LUSC) progression through BIRC [39].
CCNA2	13	Nucleus	other	CCNA2 promotes invasion and migration of non-small cell lung cancer cells through integrin αvβ3 signaling pathway [40].
CDC6	13	Nucleus	other	miR-26a/b inhibits directly migration, invasion, and proliferation of lung cancer cells by targeting CDC6 [41].
CKS1B	13	Other	kinase	CKS1B is a lung cancer-related gene, knockdown of which can result in a significant decrease in lung cancer cell proliferation, invasion and migration [42].
E2F8	13	Nucleus	transcription regulator	Depletion of E2F8 inhibits cell proliferation and tumor growth in lung cancer, thus E2F8 can be considered as a novel therapeutic target for lung cancer [43].
FOXM1	13	Nucleus	transcription regulator	Knockdown of FOXM1 inhibits the cell proliferation in LUSC [44].
ITPKA	13	Cytoplasm	kinase	ITPKA serves as an early diagnostic marker in lung cancer, whose overexpression promotes tumorigenesis [45].
MCM2	13	Nucleus	enzyme	MCM2 regulates proliferation and cell cycle in lung squamous cell carcinoma, whose overexpressed protein is obviously associated with malign differentiated degree and lymph node metastasis [46].