Table 3.

The genes with high frequency in 59 “sKLD-signaling genes” groups in the critical stage (stage IIB) for LUAD

Gene	Frequency	Location	Family*	Relation with cancer progression
PYCR1	54	Cytoplasm	enzyme	PYCR1 may be a novel therapeutic target for inhibiting cell proliferation in lung cancer [48].
ETV4	50	Nucleus	transcription regulator	ETV4 promotes proliferation and invasion of lung adenocarcinoma by transcriptionally upregulating MSI2 [49].
PITX2	50	Nucleus	transcription regulator	Knockdown of PITX2 inhibits cell proliferation, migration and invasion of LUAD [50].
MDK	49	Extracellular Space	growth factor	MDK plays an important role in non-small cell lung cancer progression and prognosis and may act as a convincing prognostic indicator for non-small cell lung cancer patients [51].
PPAT	49	Cytoplasm	enzyme	Blocking glutamine-mediated induction of PPAT inhibits cell proliferation and invasion in LUAD [52].
TOP2A	49	Nucleus	enzyme	TOP2A is an ideal candidate for miR-144-3p targets in non-small cell lung cancer and MiR-144-3p expression is significantly correlated with stage, lymph node metastasis and vascular invasion [53].
HOXC13	48	Nucleus	transcription regulator	HOXC13 promotes proliferation of lung adenocarcinoma via modulation of CCND1 and CCNE1 [54].
SRPK1	48	Nucleus	kinase	Up-regulation of SRPK1 in non-small cell lung cancer can promote the growth and migration of cancer cells [55].