Table 5.

The genes with high frequency in 20 “sKLD-signaling genes” groups in the critical stage (stage IIIB) for STAD

Gene	Frequency	Location	Family*	Relation with cancer progression
COL10A1	19	Extracellular Space	other	COL10A1 promotes invasion and metastasis in gastric cancer through transcriptional regulation of SOX9 and the involvement of the TGF-β signaling pathway [57].
BGN	18	Extracellular Space	other	BGN promote tumor invasion and metastasis of gastric cancer both in vitro and in vivo [58].
CTHRC1	18	Extracellular Space	other	CTHRC1 may be associated with metastasis in human gastric cancer [59]. Let-7b inhibits cell proliferation, migration, and invasion through targeting CTHRC1 in gastric cancer [60].
SALL4	18	Nucleus	transcription regulator	Enforced expression of SALL4 not only enhances the proliferation and migration of human gastric cancer cells, but promotes the growth and metastasis of gastric xenograft tumor in vivo [61].
MMP11	18	Extracellular Space	peptidase	Knockdown of MMP11 inhibits proliferation and invasion of gastric cancer cells [62].
MAP4K4	18	Cytoplasm	kinase	MAP4K4 overexpression promotes cancer progression or metastasis [63, 64].
SOX4	18	Nucleus	transcription regulator	MiR-211 inhibits cell proliferation and invasion of gastric cancer by down-regulating SOX4 [65].
FOXS1	17	Nucleus	transcription regulator	Overexpression of FOXS1 in gastric cancer cell lines can inhibit proliferation, metastasis, and epithelial-mesenchymal transition of tumor through downregulating wnt/β-catenin pathway [66].