Fig. 3.

WSI-based IMS vs. RNA-seq-based molecular PAM50. a Kaplan-Meier curves for Luminal A and Basal-like based on molecular PAM50 calls with HR = 1.25 and log-rank tests p = 0.39 (n = 533). b Kaplan-Meier curves for Luminal A and Basal-like based on WSI-IMS calls with HR = 1.59 and log-rank tests p = 0.06 (n = 488). c All the cases analyzed were molecularly classified as LumA, but the WSI-based system classified some of these (n = 31) as Basal (yellow); the expression levels of ESR1 and PGR for cases WSI-subtyped as Basal were lower compared to confirmed LumA (blue). d Conversely, the receptor levels of molecularly subtyped Basal cases WSI-subtyped to be LumA (n = 15) are higher than confirmed Basal cases