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. 2020 Jan 28;39:23. doi: 10.1186/s13046-019-1504-5

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Clinical significance of TRIM6 in CRC. a, The mRNA expression of TRIM6 was detected in 35 pairs of CRC samples and mucosa tissues (cohort 1) by qRT-PCR. The TRIM6 expression was normalized to GAPDH. b, The mRNA expression of TRIM6 in GSE GSE20842 dataset, which includes 65 paired samples of cancer and adjacent mucosa from patients with Stage II/III rectal adenocarcinomas. c, Representative images of immunohistochemical staining for TRIM6 in CRC samples and mucosa tissues from cohort 2. Scale bar: 100 μm. d, Survival analysis of patients with high (TRIM6^high) or low expression of TRIM6 (TRIM6^low). e, Multivariate regression analysis in cohort 2