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. 2020 Jan 29;20:18. doi: 10.1186/s12902-020-0495-8

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — AHR and AIP tumour immunohistochemistry (100x magnification). a. Only cytoplasmic AHR staining was observed in the patient’s corticotrophinoma. b, c. Both cytoplasmic and nuclear AHR staining was observed in control corticotrophinoma specimens from two men with non-cyclical Cushing’s disease and no AHR variants. d-f. Cytoplasmic and membranous staining for the AHR chaperone, AIP, was found in the corticotrophinomas from the patient (d) and the two controls (e, f)