Fig. 3.

Structure of human wild-type and mutant retinoid X receptor gamma (RXRG) protein [6]. a. Arg286 (magenta) is part of the ligand binding domain and forms a salt bridge with glutamic acid at position 241 and glutamic acid at position 282. b-c. The substitution Arg286Cys (red) was shown through homology modelling to be smaller than the wild-type Arg286 (green), which may cause loss of external interactions. The charge of the wild-type residue is also lost by this substitution, which will disturb the ionic interaction made by the wild-type residue with nearby glutamic acid residues