Table 1.
Characteristics of patients with malignant primary osseous neoplasms by lung metastasis
| Characteristic | Total, N = 4459 No. (%) |
Non-metastatic to lung, N = 3952 No. (%) |
Metastatic to lung, N = 507 No. (%) |
P |
|---|---|---|---|---|
| Age | < 0.001 | |||
| < 30 | 1810 (40.6) | 1521 (38.5) | 289 (57.0) | |
| > 30 | 2649 (59.4) | 2431 (61.5) | 218 (43.0) | |
| Race | 0.312 | |||
| White | 3667 (82.2) | 3258 (82.4) | 409 (80.7) | |
| Black | 412 (9.2) | 354 (9.0) | 58 (11.4) | |
| Other1 | 348 (7.8) | 312 (7.9) | 36 (7.1) | |
| Unknown | 32 (0.7) | 28 (0.7) | 4 (0.8) | |
| Gender | 0.005 | |||
| Male | 2530 (56.7) | 2213 (56.0) | 317 (62.5) | |
| Female | 1929 (43.3) | 1739 (44.0) | 190 (37.5) | |
| Primary site | < 0.001 | |||
| Extremity | 2273 (51.0) | 1973 (49.9) | 300 (59.2) | |
| Axial | 2186 (49.0) | 1979 (50.1) | 207 (40.8) | |
| Grade | < 0.001 | |||
| Low grade | 1144 (25.7) | 1117 (28.3) | 27 (5.3) | |
| High grade | 1606 (36.0) | 1343 (34.0) | 263 (51.9) | |
| Unknown | 1709 (38.3) | 1492 (37.8) | 217 (42.8) | |
| Tumor size | < 0.001 | |||
| < 5 | 1029 (23.1) | 1000 (25.3) | 29 (5.7) | |
| > 5 | 2667 (59.8) | 2309 (58.4) | 358 (70.6) | |
| Unknown | 763 (17.1) | 643 (16.3) | 120 (23.7) | |
| Histology type | < 0.001 | |||
| Osteosarcoma | 1457 (32.7) | 1225 (31.0) | 232 (45.8) | |
| Ewing sarcoma | 592 (13.3) | 481 (12.2) | 111 (21.9) | |
| Chondrosarcoma | 1292 (29.0) | 1223 (30.9) | 69 (13.6) | |
| Squamous cell carcinoma | 72 (1.6) | 68 (1.7) | 4 (0.8) | |
| Spindle cell sarcoma | 54 (1.2) | 45 (1.1) | 9 (1.8) | |
| Chordoma | 461 (10.3) | 456 (11.5) | 5 (1.0) | |
| Giant cell sarcoma | 112 (2.5) | 98 (2.5) | 14 (2.8) | |
| Small cell sarcoma | 5 (0.1) | 3 (0.1) | 2 (0.4) | |
| Epithelioid sarcoma | 23 (0.5) | 19 (0.4) | 4 (0.8) | |
| Small round cell tumor | 5 (0.1) | 3 (0.1) | 2 (0.4) | |
| Fibrosarcoma | 62 (1.4) | 54 (1.4) | 8 (1.6) | |
| Adamantinoma | 17 (0.4) | 17 (0.4) | 0 (0) | |
| Hemangiosarcoma | 50 (1.1) | 46 (1.2) | 4 (0.8) | |
| Synovial sarcoma | 16 (0.4) | 12 (0.3) | 4 (0.8) | |
| Leiomyosarcoma | 25 (5.6) | 24 (0.9) | 1 (0.2) | |
| Other | 216 (4.8) | 178 (4.5) | 38 (7.5) |
SEER 2010–2015
1Including American Indian/Alaska Native, Asian/Pacific Islander