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. 2020 Jan 28;18:11. doi: 10.1186/s12915-019-0731-8

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 11. — a Phylogenetic tree of gnathostome ASC protein sequences. Maximum Likelihood phylogenetic tree with 500 bootstraps rooted at the split between tetrapods and ray-finned fish. Tetrapods were used as outgroup. Round goby is indicated in orange. Gobiidae are highlighted with a gray box. The goby sequences form a clear separate cluster, with a large expansion apparent in the round goby. b Phylogenetic tree of gnathostome Caspase 1 protein sequences The Caspase 1 tree comprises all protein sequences annotated as CASP1 in the investigated Gobiidae genomes aligned together with reference sequences from Ensembl and GenBank. The root was placed on the branch containing the mammalian sequences