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. 2020 Jan 28;18:11. doi: 10.1186/s12915-019-0731-8

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5. — Phylogenetic tree of vertebrate CYP protein sequences. Maximum likelihood phylogenetic tree of round goby (Neogobius melanostomus), zebrafish (Danio rerio), human (Homo sapiens), chicken (Gallus gallus), frog (Xenopus laevis), mouse (Mus musculus), and rat (Rattus norvegicus), with 100 bootstraps, rooted with the CYP51 family. Detoxification genes CYP1–3 do not feature expansions, while a family with largely unknown function, CYP8, is expanded to six members (see gray boxes). Non-fish vertebrates are indicated in gray. Gene fragments too short for tree building but attributable to a certain family are indicated by orange half circles next to the root of the respective family