Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 28;18:11. doi: 10.1186/s12915-019-0731-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 8. — The inflammasome pathway. Pathogen-associated patterns are recognized by pattern recognition receptors such as Toll-like receptors at the cell surface (TLRs), or NACHT domain and Leucine-rich Repeat containing receptor (NLRs) in the cytoplasm. This interaction triggers the transcription of cytokine precursors via NFkB, and the activation and assembly of inflammasome components (NLRs, Pro-Caspase-1, and ASC). Inflammasome-activated Caspase 1 then initiates the maturation of cytokines and an acute phase inflammatory response (CRP, APCS proteins), and/or pyroptosis through gasdermin. Several components of the pathway are expanded in the round goby (gene numbers in round goby, or novel groups for NLRs, are indicated in orange)