Table 4.

NLR-C characteristics

Group	Identified in this study	Walker A	Last residues of the largest exon	PYD?	B30.2?
1		GIAGVGKT	L(I/M)PVVKNT(T/R)RA	+	+
2		GVAGIGKS	LSAVIKTSKRA	+	+
3		GIAGIGKT	L(IP/TA)AV(R/S)NC(RK/TR/RR)A	−	+
4		GVAGIGKT	LPV(I/V)xxxx(A/V)x	−	−
5	x	GVAG(V/I)GKT	(L/M)PV(V/I)KASxK(A/V)	+	+
6	x	GVAGVGKT	L(I/V)P(A/V)VRNCRKA	−	−

Key features of each of the six NLR-C subgroups as identified from zebrafish (Danio rerio) and round goby. Each of the groups is characterized by the presence of a highly conserved Walker A Motif and either the presence or absence of specific C- and N-terminal domains (PYD and B30.2). x denotes a variable amino acid, + and − denote whether the denoted domains are characteristically present/absent in the group