Table 2.

Multivariate analysis for OS, NRM, and CIR

Variables	n (%)	OS			NRM			CIR
		Multivariate analysis			Multivariate analysis			Multivariate analysis
		HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Clinical factors
Age (<51 y)	150 (48.4)							1.55	0.80-3.29	.194
Male sex	181 (58.4)							1.12	0.60-2.12	.729
HCT-CI, <3	114 (36.8)	0.41	0.26-0.63	.002	0.58	0.32-0.88	.008
R-DRI		2.35	1.15-5.48	<.001	1.24	1.02-2.58	.046	1.38	1.04-1.78	<.001
Low risk	82 (26.4)	0.62	0.34-1.26	.140	0.44	0.21-1.09	.082	0.75	0.58-0.97	.033
Intermediate risk	92 (29.7)	1.00	Ref.		1	Ref.		1.00	Ref.
High risk	70 (22.6)	2.27	1.22-3.59	.002	1.34	0.59-3.02	.550	1.84	1.04-3.34	.038
Very high risk	66 (21.3)	6.15	1.83-6.03	<.001	1.98	0.98-4.35	.061	4.73	2.52-7.15	<.001
Conditioning regimens (RIC)	199 (64.2)				0.87	0.4-1.08	.060	0.80	0.39-1.57	.489
Donor relation (related donor)	84 (27.1)							1.24	0.88-1.20	.192
HLA compatibility (HLA match)	173 (55.8)	0.89	0.49-1.59	.688				0.86	0.51-1.24	.317
Stem cell sources
CB	136 (43.9)	0.66	0.30-1.41	.281				0.60	0.36-1.02	.060
BM	119 (38.4)	1.00	Ref.					1.00	Ref.
PBSC	55 (17.7)	0.79	0.45-1.41	.432				1.21	0.66-2.15	.482
Sex mismatch (female to male)	75 (24.2)				2.74	0.94-7.62	.059	0.81	0.52-1.15	.162
Diagnosis to transplant (<180 d)	146 (47.1)							0.69	0.63-0.99	.049
Grade 2-4 acute GVHD by day 100	130 (42.0)	0.93	0.61-1.42	.729	1.58	1.01-2.48	.046	0.65	0.41-1.00	.051
Immunologic factors
CD20+ B cell (high)	135 (43.5)	0.39	0.20-0.74	<.001	0.34	0.11-0.68	.007
CD8+CD11b− T cell (high)	194 (62.6)	0.40	0.24-0.69	<.001	0.35	0.22-0.49	.004
CD3−CD56+ NK cell (high)	210 (67.7)	0.65	0.39-1.08	.090	0.51	0.47-1.84	.290
CD16+CD57− NK cell (high)	185 (59.7)	0.31	0.18-0.82	<.001	0.92	0.43-1.15	.081	0.38	0.24-0.80	.009
CD16+CD57+ NK cell (high)	162 (52.3)	0.75	0.43-1.30	.306	0.89	0.41-2.50	.870	0.51	0.26-0.94	.034