Table 3.
Updated diagnostic accuracy of ultrasonography and iuMRI by gestational age of fetus
|
Meridian |
Meridian 3-year follow-up |
|||||
|---|---|---|---|---|---|---|
| Ultrasonography correct | iuMRI correct | Ultrasonography correct | iuMRI correct | Percentage difference (95% CI) | p value* | |
| 18–23 weeks (n=372) | 256/369 (70%) | 341/369 (92%) | 257/372 (69%) | 339/372 (91%) | 22% (17–27) | <0·0001 |
| ≥24 weeks (n=202) | 129/201 (64%) | 188/201 (94%) | 130/202 (64%) | 190/202 (94%) | 30% (23–37) | <0·0001 |
| Combined (n=574) | 387/570 (68%) | 529/570 (93%) | 387/574 (67%) | 529/574 (92%) | 25% (21–29) | <0·0001 |
Data are n/N (%), unless otherwise indicated. The 574 fetuses include the 570 fetuses included in the original MERIDIAN primary analysis (had iuMRI within 2 weeks of ultrasonography and had outcome reference diagnosis). There were four further cases that now have an outcome reference diagnosis from the 3-year data, increasing the number to 574. Four of the original cases also had updated outcome reference diagnosis from the 3-year data. The updated diagnostic accuracy is based on new neuroimaging studies up to age 3 years and presented as a percentage along with the percentages correct from the original MERIDIAN study for reference. iuMRI=in-utero MRI.
McNemar's test between ultrasound and iuMRI correct diagnoses.