Table 4.
Outcomes of infants based on in-utero ultrasonography and iuMRI prognosis where imaging was done within 2 weeks of each other, along with specificities, sensitivities, PPV and NPV
|
Developmental assessment (surviving infants) |
In-utero death, stillbirth or infant death (n=65) | |||
|---|---|---|---|---|
| Normal or at risk (n=111) | Abnormal (n=45) | |||
| Ultrasonography | ||||
| Normal or favourable (≤10%) | 56 | 13 | 11 | |
| Specificity | 50% (41–60) | .. | .. | |
| NPV (surviving infants only) | 81% (70–89) | .. | .. | |
| Intermediate (11–50%) | 28 | 11 | 15 | |
| Poor (>50%) | 5 | 9 | 27 | |
| Sensitivity | .. | 20% (11–34) | 42% (30–54) | |
| PPV (surviving infants only) | .. | 64% (39–84) | NA | |
| Unknown | 22 | 12 | 12 | |
| iuMRI | ||||
| Normal or favourable (≤10%) | 76 | 19 | 10 | |
| Specificity | 68% (59–76) | .. | .. | |
| NPV (surviving infants only) | 80% (71–87) | .. | .. | |
| Intermediate (11–50%) | 20 | 12 | 16 | |
| Poor (>50%) | 5 | 11 | 31 | |
| Sensitivity | .. | 24% (14–39) | 48% (36–60) | |
| PPV (surviving infants only) | .. | 69% (44–86) | NA | |
| Unknown | 10 | 3 | 8 | |
Data are n or % (95% CI). Prognosis following in-utero scan (chance of abnormal development as assigned by clinician). NA=not applicable. iuMR=in-utero MRI. NPV=negative predictive value. PPV=positive predictive value.