Heat maps depict how (A) KAM, (B) ATS, and (C) ITR individually influence absolute MCL strain relative to each combination of the other 2 loading conditions. The highest strains are observed when the KAM loading condition is in the very-high-risk state. Note that for each plot, the effect of the isolated loading factor is observed along the tertiary (y) axis, while the remaining combinatorial loading is depicted along the primary (x) axis. Moving from left to right along the tertiary axis on each plot, KAM affects a steeper increase in strain than ATS or ITR. ATS, anterior tibial shear; ITR, internal tibial rotation; KAM, knee abduction moment; MCL, medial collateral ligament.