Table 1.

Urinalysis of male and female rats

Parameters	Result	Dose (mg/kg/day)
		Male				Female
		0	500	1000	2000	0	500	1000	2000
Glucose (mg/dL)	Negative	10	10	10	10	10	10	10	10
Bilirubin (mg/dL)	Negative	9	8	9	6	10	10	9	10
	1	1	2	1	4	0	0	1	0
Ketone body (mg/dL)	Negative	0	0	0	0	7	1	2	1
	5 (trace)	5	6	4	0	2	7	7	8
	15	5	4	6	8	1	0	1	1
	50	0	0	0	2	0	2	0	0
Specific gravity	1.011–1.020	0	0	0	0	2	0	0	0
	1.021–1.030	0	0	0	0	2	0	0	0
	1.031–1.040	0	0	1	0	2	2	1	1
	1.041–1.050	1	2	2	4	1	3	6	5
	1.051–1.060	3	5	3	1	3	2	2	2
	≥ 1.060	6	3	4	5	0	3	1	2
pH	6.0	0	0	1	2	1	3	3	4
	6.5	0	2	7	5	0	0	3	3
	7.0	5	3	2	3	0	1	2	0
	8.0	2	3	0	0	9	3	2	2
	9.0	3	2	0	0	0	3	0	1
Protein (mg/dL)	Negative	0	2	0	0	8	3	4	2
	25 (trace)	8	7	9	8	2	6	5	8
	75	2	1	1	2	0	1	1	0
Occult blood (Ery/uL)	Negative	7	8	7	7	9	10	10	10
	10	3	2	2	3	0	0	0	0
	25	0	0	0	0	1	0	0	0
	250	0	0	1	0	0	0	0	0
RBC (Ery/uL)	0	10	10	9	10	10	10	10	10
	> 100	0	0	1	0	0	0	0	0
WBC (Leko/uL)	0	10	10	10	10	10	10	10	10
Epithelial cell (mean/20 fields)	0	10	10	10	10	10	10	10	10
Casts (mean/field)	0	10	10	10	10	10	10	10	10
Urine color	Pale yellow	1	2	0	0	6	0	1	0
	Yellow	9	8	9	10	4	10	9	10
	Amber	0	0	1	0	0	0	0	0
Transparency	Clear	3	6	8	6	10	8	10	10
	Mild turbidity	7	4	1	3	0	1	0	0
	Turbidity	0	0	1	1	0	1	0	0
Urine volume* (mL/24 h)		7.5 ± 2.9	7.3 ± 3.4	8.8 ± 2.8	8.4 ± 4.3	9.7 ± 4.1	6.6 ± 3.1	7.7 ± 3.5	6.6 ± 2.4
No. of animals		10	10	10	10	10	10	10	10

*Values are mean ± SD