Table 2.
Hematological values of male and female rats
| Items | Dose (mg/kg/day) | |||
|---|---|---|---|---|
| 0 | 500 | 1000 | 2000 | |
| Male | ||||
| RBC (106/μL) | 8.62 ± 0.35 | 8.84 ± 0.33 | 8.75 ± 0.38 | 8.82 ± 0.14 |
| Hemoglobin (g/dL) | 14.8 ± 0.5 | 14.7 ± 0.4 | 14.9 ± 0.7 | 14.7 ± 0.4 |
| Hematocrit (%) | 46.2 ± 1.4 | 46.0 ± 0.9 | 46.4 ± 1.7 | 45.9 ± 0.9 |
| MCV (fL) | 53.7 ± 1.3 | 52.1 ± 1.7 | 53.0 ± 1.2 | 52.1 ± 1.6 |
| MCH (pg) | 17.2 ± 0.4 | 16.6 ± 0.6 | 17.1 ± 0.6 | 16.7 ± 0.6 |
| MCHC (g/μL) | 32.0 ± 0.6 | 31.9 ± 0.4 | 32.2 ± 0.6 | 32.0 ± 0.3 |
| Platelet (103/μL) | 939 ± 94 | 967 ± 70 | 885 ± 97 | 982 ± 126 |
| Reticulocyte (%) | 3.14 ± 1.38 | 2.59 ± 0.49 | 2.62 ± 0.49 | 2.34 ± 0.37 |
| WBC (103/μL) | 9.82 ± 2.12 | 9.39 ± 3.17 | 9.56 ± 2.01 | 9.61 ± 2.23 |
| Neutrophils (%) | 23.8 ± 6.5 | 24.5 ± 8.5 | 19.1 ± 6.0 | 23.1 ± 7.9 |
| Lymphocytes (%) | 71.6 ± 6.8 | 70.8 ± 9.2 | 75.9 ± 6.2 | 71.6 ± 8.3 |
| Monocytes (%) | 2.3 ± 0.5 | 2.2 ± 0.6 | 2.4 ± 0.6 | 2.7 ± 1.0 |
| Eosinophils (%) | 1.1 ± 0.3 | 1.4 ± 0.5 | 1.4 ± 0.3 | 1.3 ± 0.2 |
| Basophils (%) | 0.3 ± 0.1 | 0.2 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 |
| PT (second) | 18.1 ± 0.3 | 18.3 ± 0.9 | 18.5 ± 1.0 | 18.8 ± 0.5 |
| APTT (second) | 16.8 ± 1.5 | 17.1 ± 0.6 | 17.1 ± 1.3 | 16.9 ± 1.3 |
| No. of animals | 10 | 10 | 10 | 10 |
| Female | ||||
| RBC (106/μL) | 8.10 ± 0.36 | 7.95 ± 0.41 | 8.04 ± 0.35 | 8.10 ± 0.32 |
| Hemoglobin (g/dL) | 14.4 ± 0.5 | 14.3 ± 0.8 | 14.6 ± 0.6 | 14.5 ± 0.4 |
| Hematocrit (%) | 44.2 ± 1.4 | 43.6 ± 2.2 | 44.3 ± 2.1 | 43.8 ± 1.2 |
| MCV (fL) | 54.6 ± 1.8 | 54.8 ± 1.1 | 55.1 ± 1.6 | 54.1 ± 1.6 |
| MCH (pg) | 17.8 ± 0.7 | 18.0 ± 0.4 | 18.2 ± 0.6 | 17.9 ± 0.6 |
| MCHC (g/μL) | 32.7 ± 0.4 | 32.8 ± 0.5 | 33.0 ± 0.6 | 33.1 ± 0.4 |
| Platelet (103/μL) | 926 ± 64 | 906 ± 90 | 937 ± 111 | 998 ± 162 |
| Reticulocyte (%) | 2.31 ± 0.37 | 2.18 ± 0.32 | 2.58 ± 1.07 | 2.59 ± 0.86 |
| WBC (103/μL) | 4.36 ± 1.49 | 4.61 ± 0.71 | 5.21 ± 1.24 | 6.32 ± 2.28 |
| Neutrophils (%) | 18.2 ± 4.2 | 17.7 ± 5.5 | 22.2 ± 12.4 | 22.1 ± 10.6 |
| Lymphocytes (%) | 76.6 ± 4.4 | 77.5 ± 6.0 | 72.5 ± 12.8 | 73.0 ± 10.8 |
| Monocytes (%) | 2.2 ± 0.6 | 2.0 ± 0.5 | 2.5 ± 0.8 | 2.0 ± 0.7 |
| Eosinophils (%) | 1.9 ± 0.5 | 1.8 ± 0.8 | 1.5 ± 0.4 | 1.8 ± 0.9 |
| Basophils (%) | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
| PT (second) | 18.1 ± 0.6 | 18.0 ± 0.7 | 18.0 ± 0.9 | 18.9 ± 1.0 |
| APTT (second) | 14.2 ± 0.7 | 13.6 ± 1.4 | 13.7 ± 2.3 | 14.6 ± 1.5 |
| No. of animals | 10 | 10 | 10 | 10 |
Values are mean ± SD
RBC red blood cell count, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, WBC white blood cell count, PT prothrombin time, APTT active partial thromboplastin time