Table 3.
Serum biochemical values of male and female rats
| Items | Dose (mg/kg/day) | |||
|---|---|---|---|---|
| 0 | 500 | 1000 | 2000 | |
| Male | ||||
| ALT (IU/L) | 32.9 ± 10.5 | 29.1 ± 11.1 | 28.7 ± 4.1 | 36.4 ± 27.7 |
| AST (IU/L) | 97.4 ± 18.9 | 103.1 ± 37.4 | 97.6 ± 21.4 | 116.7 ± 57.4 |
| ALP (IU/L) | 302.9 ± 77.2 | 269.7 ± 74.2 | 288.8 ± 54.5 | 246.2 ± 42.5 |
| GGT (IU/L) | 0.33 ± 0.11 | 0.39 ± 0.21 | 0.33 ± 0.10 | 0.79 ± 1.39 |
| Glucose (mg/dL) | 129 ± 9 | 132 ± 8 | 130 ± 12 | 132 ± 10 |
| BUN (mg/dL) | 12.3 ± 1.4 | 12.7 ± 1.7 | 12.7 ± 1.3 | 12.6 ± 1.5 |
| Creatinine (mg/dL) | 0.45 ± 0.04 | 0.47 ± 0.03 | 0.47 ± 0.03 | 0.46 ± 0.03 |
| TBil (mg/dL) | 0.06 ± 0.02 | 0.05 ± 0.02 | 0.03 ± 0.02 | 0.06 ± 0.05 |
| TCho (mg/dL) | 74 ± 18 | 75 ± 19 | 70 ± 12 | 82 ± 19 |
| Triglyceride (mg/dL) | 60 ± 26 | 59 ± 29 | 59 ± 27 | 55 ± 23 |
| TP (g/dL) | 5.9 ± 0.1 | 6.1 ± 0.3 | 6.0 ± 0.2 | 6.0 ± 0.3 |
| Albumin (g/dL) | 2.4 ± 0.1 | 2.4 ± 0.1 | 2.4 ± 0.1 | 2.4 ± 0.1 |
| A/G (ratio) | 0.68 ± 0.03 | 0.67 ± 0.05 | 0.69 ± 0.04 | 0.68 ± 0.06 |
| IP (mg/dL) | 5.70 ± 0.49 | 5.82 ± 0.43 | 6.03 ± 0.62 | 5.81 ± 0.56 |
| Ca (mg/dL) | 10.0 ± 0.2 | 10.1 ± 0.2 | 10.0 ± 0.3 | 10.0 ± 0.3 |
| Na+ (mmol/L) | 138.4 ± 1.6 | 138.5 ± 1.1 | 138.3 ± 0.7 | 137.9 ± 1.4 |
| K+ (mmol/L) | 4.22 ± 0.15 | 4.28 ± 0.23 | 4.23 ± 0.23 | 4.27 ± 0.16 |
| Cl− (mmol/L) | 106.4 ± 1.6 | 106.8 ± 0.9 | 106.3 ± 1.1 | 106.2 ± 1.6 |
| No. of animals | 10 | 10 | 10 | 10 |
| Female | ||||
| ALT (IU/L) | 27.3 ± 7.3 | 27.4 ± 5.9 | 31.3 ± 24.7 | 30.0 ± 21.7 |
| AST (IU/L) | 88.3 ± 23.8 | 97.6 ± 19.2 | 119.0 ± 51.6 | 103.7 ± 48.1 |
| ALP (IU/L) | 133.2 ± 49.8 | 149.9 ± 46.5 | 152.5 ± 26.4 | 143.2 ± 35.1 |
| GGT (IU/L) | 0.59 ± 0.15 | 0.73 ± 0.34 | 0.64 ± 0.30 | 0.67 ± 0.14 |
| Glucose (mg/dL) | 129 ± 9 | 133 ± 9 | 134 ± 16 | 129 ± 8 |
| BUN (mg/dL) | 14.6 ± 1.7 | 14.2 ± 2.1 | 14.1 ± 1.4 | 14.1 ± 1.3 |
| Creatinine (mg/dL) | 0.51 ± 0.03 | 0.51 ± 0.04 | 0.51 ± 0.04 | 0.51 ± 0.04 |
| TBil (mg/dL) | 0.09 ± 0.04 | 0.07 ± 0.01 | 0.08 ± 0.05 | 0.08 ± 0.04 |
| TCho (mg/dL) | 82 ± 15 | 91 ± 22 | 91 ± 25 | 97 ± 23 |
| Triglyceride (mg/dL) | 22 ± 9 | 30 ± 12 | 30 ± 14 | 40 ± 33 |
| TP (g/dL) | 6.4 ± 0.4 | 6.5 ± 0.3 | 6.5 ± 0.5 | 6.4 ± 0.4 |
| Albumin (g/dL) | 2.9 ± 0.2 | 2.9 ± 0.3 | 3.0 ± 0.3 | 2.8 ± 0.3 |
| A/G (ratio) | 0.82 ± 0.04 | 0.82 ± 0.09 | 0.83 ± 0.07 | 0.80 ± 0.10 |
| IP (mg/dL) | 4.34 ± 0.82 | 4.55 ± 0.44 | 4.70 ± 0.56 | 4.70 ± 0.57 |
| Ca (mg/dL) | 10.0 ± 0.4 | 10.0 ± 0.4 | 10.0 ± 0.4 | 10.0 ± 0.3 |
| Na+ (mmol/L) | 137.7 ± 1.0 | 137.6 ± 1.0 | 137.4 ± 0.9 | 136.9 ± 1.6 |
| K+ (mmol/L) | 4.04 ± 0.24 | 3.95 ± 0.19 | 4.03 ± 0.27 | 3.91 ± 0.37 |
| Cl− (mmol/L) | 107.8 ± 1.4 | 107.5 ± 1.4 | 107.0 ± 1.3 | 106.7 ± 1.3 |
| No. of animals | 10 | 10 | 10 | 10 |
Values are mean ± SD
ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, GGT gamma glutamyl transpeptidase, BUN blood urea nitrogen, TBil total bilirubin, TCho total cholesterol, TP total protein, A/G albumin/globulin, IP inorganic phosphorus