Table 4.

Absolute and relative organ weights of male and female rats

Items	Dose (mg/kg/day)
	0	500	1000	2000
Male
Body weighta (g)	535.8 ± 63.9	539.3 ± 50.8	532.2 ± 48.4	547.1 ± 48.6
Brain (g)	2.18 ± 0.10	2.16 ± 0.11	2.13 ± 0.09	2.15 ± 0.07
% to body weight	0.41 ± 0.05	0.40 ± 0.03	0.40 ± 0.04	0.40 ± 0.03
Pituitary (g)	0.0117 ± 0.0019	0.0122 ± 0.0018	0.0120 ± 0.0013	0.0122 ± 0.0014
% to body weight	0.0022 ± 0.0003	0.0023 ± 0.0002	0.0023 ± 0.0002	0.0022 ± 0.0002
Heart (g)	1.55 ± 0.16	1.57 ± 0.12	1.55 ± 0.08	1.59 ± 0.15
% to body weight	0.29 ± 0.02	0.29 ± 0.02	0.29 ± 0.02	0.29 ± 0.02
Lungs (g)	1.62 ± 0.15	1.72 ± 0.07	1.67 ± 0.17	1.64 ± 0.19
% to body weight	0.30 ± 0.03	0.32 ± 0.03	0.32 ± 0.03	0.30 ± 0.03
Liver (g)	13.36 ± 2.36	14.19 ± 2.09	13.33 ± 1.52	14.29 ± 2.18
% to body weight	2.49 ± 0.22	2.62 ± 0.23	2.50 ± 0.13	2.60 ± 0.19
Spleen (g)	0.96 ± 0.18	1.02 ± 0.36	0.93 ± 0.10	0.91 ± 0.11
% to body weight	0.18 ± 0.03	0.19 ± 0.06	0.18 ± 0.02	0.17 ± 0.02
Kidneys (g)	3.24 ± 0.37	3.22 ± 0.33	3.19 ± 0.21	3.38 ± 0.43
% to body weight	0.61 ± 0.07	0.60 ± 0.04	0.60 ± 0.05	0.62 ± 0.04
Adrenals (g)	0.0622 ± 0.0094	0.0601 ± 0.0081	0.0572 ± 0.0097	0.0618 ± 0.0093
% to body weight	0.0116 ± 0.0015	0.0112 ± 0.0013	0.0109 ± 0.0021	0.0113 ± 0.0017
Testes (g)	3.59 ± 0.2	3.60 ± 0.23	3.60 ± 0.34	3.43 ± 0.32
% to body weight	0.68 ± 0.12	0.67 ± 0.04	0.68 ± 0.08	0.63 ± 0.08
Prostate gland (g)	0.59 ± 0.20	0.55 ± 0.17	0.60 ± 0.16	0.61 ± 0.13
% to body weight	0.11 ± 0.04	0.10 ± 0.03	0.11 ± 0.04	0.11 ± 0.03
No. of animals	10	10	10	10
Female
Body weighta (g)	285.5 ± 27.4	296.5 ± 24.3	297.2 ± 28.3	289.0 ± 30.1
Brain (g)	1.96 ± 0.10	2.03 ± 0.11	1.98 ± 0.10	2.03 ± 0.08
% to body weight	0.69 ± 0.08	0.69 ± 0.07	0.67 ± 0.07	0.71 ± 0.07
Pituitary (g)	0.0162 ± 0.0028	0.0180 ± 0.0046	0.0171 ± 0.0024	0.0175 ± 0.021
% to body weight	0.0057 ± 0.0010	0.0061 ± 0.0014	0.0058 ± 0.0007	0.0061 ± 0.0009
Heart (g)	0.95 ± 0.07	0.96 ± 0.09	0.98 ± 0.07	0.98 ± 0.12
% to body weight	0.33 ± 0.02	0.32 ± 0.02	0.33 ± 0.02	0.34 ± 0.02
Lungs (g)	1.16 ± 0.14	1.19 ± 0.19	1.16 ± 0.08	1.22 ± 0.06
% to body weight	0.41 ± 0.02	0.40 ± 0.05	0.39 ± 0.03	0.43 ± 0.04
Liver (g)	7.02 ± 0.71	7.60 ± 0.82	7.66 ± 0.84	7.67 ± 1.02
% to body weight	2.47 ± 0.21	2.57 ± 0.24	2.58 ± 0.23	2.65 ± 0.19
Spleen (g)	0.54 ± 0.07	0.56 ± 0.09	0.61 ± 0.08	0.63 ± 0.05*
% to body weight	0.19 ± 0.02	0.19 ± 0.03	0.20 ± 0.02	0.22 ± 0.03*
Kidneys (g)	1.81 ± 0.15	1.94 ± 0.20	1.89 ± 0.13	1.93 ± 0.17
% to body weight	0.64 ± 0.05	0.66 ± 0.07	0.64 ± 0.06	0.67 ± 0.03
Adrenals (g)	0.0672 ± 0.0066	0.0720 ± 0.0163	0.0727 ± 0.0082	0.0697 ± 0.0111
% to body weight	0.0236 ± 0.0021	0.0244 ± 0.0052	0.0247 ± 0.0035	0.0242 ± 0.0034
Ovary (g)	0.0823 ± 0.0153	0.0856 ± 0.0180	0.0858 ± 0.0102	0.0857 ± 0.0221
% to body weight	0.0288 ± 0.0042	0.0290 ± 0.0060	0.0291 ± 0.0048	0.0298 ± 0.0074
Uterus (g)	0.65 ± 0.24	0.72 ± 0.26	0.81 ± 0.30	0.73 ± 0.21
% to body weight	0.23 ± 0.09	0.24 ± 0.09	0.27 ± 0.10	0.26 ± 0.08
No. of animals	10	10	10	10

Significantly different from vehicle control: *p< 0.05. Values are mean ± SD

^aThe body weights were measured right before necropsy after overnight fasting