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. Author manuscript; available in PMC: 2020 Jan 29.
Published in final edited form as: Int Arch Allergy Immunol. 2018 Aug 27;177(3):181–191. doi: 10.1159/000490152

Fig. 2.

Fig. 2.

Concentration-dependence of histamine release from basophils stimulated with 6061P monoclonal anti-IgE Ab in two experimental designs. Panel A; endogenous IgE on basophils was dissociated with lactic acid treatment and the cells re-sensitized to obtain two densities of cell surface IgE and the cells stimulated with monoclonal anti-IgE Ab (n=4). Panel B; from a group of 14 basophil donors with a natural range of cell surface IgE densities, two groups of the extremes of density were formed (n=3) at high density vs. (n=4) at low density. The anti-IgE Ab concentration-dependence curves for histamine release for the two groups are shown as is the absolute density of cell surface IgE density. Panel C; n=13 6061P concentration-dependence curves obtained from patients being treated with omalizumab, (●) before and (□) during treatment [24].