Table 2.
CHA2DS2-VASc score and initiated anticoagulant treatment in patients with newly diagnosed atrial fibrillation
| Variable | Intervention arm | Control arm | |
|---|---|---|---|
|
| |||
| Screen-detected AF, N= 28 | Regularly detected AF, N= 95 | Regularly detected AF, N= 117 | |
| Mean CHA2DS2-VASc scorea (SD) | 3.6 (1.6) | 4.0 (1.5) | 3.9 (1.5) |
| CHA2DS2-VASc score 1, n (%) | 3 (10.7) | 6 (6.3) | 3 (2.6) |
| Female, n (%) | 15 (53.6) | 51 (53.7) | 71 (60.7) |
| CHA2DS2-VASc score 2 in females, n (%) | 0 (0.0) | 4 (7.8) | 8 (11.3) |
|
| |||
| Initiation of anticoagulant treatment,bn (%) | |||
| VKA | 18 (64.3) | 45 (47.4) | 68 (58.1) |
| NOAC | 5 (17.9) | 41 (43.2) | 34 (29.1) |
| Antiplatelet | 0 (0.0) | 1 (1.1) | 4c (3.4) |
|
| |||
| Details about anticoagulant treatment, n (%) | |||
| According to guidelinesd | 26 (92.9) | 89 (93.7) | 106 (90.6) |
| Intended deviation from guidelinese | 1 (3.6) | 4 (4.2) | 5 (4.3) |
| Unintended deviation from guidelinesf | 1 (3.6) | 2 (2.1) | 6 (5.1) |
CHA2DS2-VASc = Congestive heart failure (1 point); Hypertension (1 point); Age >75 years (2 points); Diabetes mellitus (1 point); Stroke including ischaemic stroke or transient ischaemic attack (2 points); Vascular disease including myocardial infarction, angina pectoris, coronary intervention, peripheral artery disease, arterial, or venous thrombosis (1 point); Age 65–75 years (1 point).
Initiation of oral anticoagulant (OAC) treatment: some patients used OAC before diagnoses for mechanical heart valve or venous thromboembolism (VTE) (either lifelong prescription due to multiple VTE or temporary for recent first VTE); this was 2 for AF detection by screening, 4 for detection in usual care of intervention arm, and 4 for detection in control arm.
Including two cases in whom either fragmin or clopidogrel was initiated.
Treatment according to the Dutch College of General Practitioners guideline for patients treated in primary care and the European Society of Cardiologists guideline for patients treated in hospital.6,7
Documented reason for deviation.
No documented reason for deviation from guidelines. AF = atrial fibrillation. NOAC = novel oral anticoagulants. SD = standard deviation. VKA = vitamin K antagonists.