Figure 3.

Intranasal delivery of mesenchymal stromal cells (MSCs) improves lung vascularization. A, Hematoxylin and eosin stained lung sections show a trend towards a decreased number of blood vessels in the hyperoxic injured bronchopulmonary dysplasia group (BPD). MSC therapy tended to have a higher blood vessel number. Measurements expressed as mean ± SEM and included all animals. Black arrows depict pulmonary vessels. Veh, vehicle. Scale bar = 100 μm, magnification at ×20. B, Von Willebrand Factor staining (magenta) of room air control animals (RA), BPD, and BPD + MSC depict pulmonary vascular development was restored after intranasal stem cell treatment. *P < .05 compared to BPD. Scale bar = 100 μm