Figure 5.

PCR gene array data demonstrates mesenchymal stromal cell (MSC) treatment in animals with hyperoxic lung injury influences biological processes, cellular components, and molecular function. A, A comparison analysis of gene expression was performed using the RT2 Profiler PCR Array for Rat Endothelial Cell Biology between the following animal groups: room air (RA) control, hyperoxia‐induced bronchopulmonary dysplasia (BPD), and BPD treated with MSCs (BPD + MSC). RNA was analyzed from rat lung tissue on day 20‐21 and included all animal lungs. Using a threshold of twofold expression change and statistical significance of P < .05, two separate genes were identified among the 3 groups. B, Genes differentially expressed in RA control animals compared to animals exposed to hyperoxia‐induced BPD and treated with MSCs