Table 5.
Subgroup analysis of the relationship between leukocyte count quartiles and risk of adverse clinical outcomes at 3-month follow-up.
| Q1 | Q2 | Q3 | Q4 | P for trend | P for interaction | |
|---|---|---|---|---|---|---|
| RECURRENCE OF STROKE | ||||||
| Age | ||||||
| <60 years | 0.5605 | |||||
| Adjusted OR (95%CI) | 1 | 1.306 (0.729–2.338) |
1.561 (0.891–2.734) |
2.090 (1.226–3.565) |
0.0031 | |
| ≥60 years | ||||||
| Adjusted OR (95%CI) | 1 | 1.022 (0.763–1.369) |
1.243 (0.938–1.647) |
1.676 (1.282–2.189) |
<0.0001 | |
| Sex | ||||||
| Male | 0.4876 | |||||
| Adjusted OR (95%CI) | 1 | 0.877 (0.622–1.237) |
1.047 (0.754–1.454) |
1.667 (1.227–2.264) |
0.0002 | |
| Female | ||||||
| Adjusted OR (95%CI) | 1 | 1.427 (0.956–2.131) |
1.788 (1.212–2.640) |
1.970 (1.349–2.877) |
0.0002 | |
| Hypertension | ||||||
| Without | 0.9570 | |||||
| Adjusted OR (95%CI) | 1 | 1.378 (0.856–2.219) |
1.803 (1.140–2.850) |
1.948 (1.237–3.066) |
0.0020 | |
| With | ||||||
| Adjusted OR (95%CI) | 1 | 0.982 (0.719–1.340) |
1.160 (0.860–1.565) |
1.741 (1.316–2.304) |
<0.0001 | |
| Previous stroke or transient ischemic attack | ||||||
| Without | 0.9646 | |||||
| Adjusted OR (95%CI) | 1 | 1.201 (0.848–1.701) |
1.447 (1.031–2.031) |
1.902 (1.374–2.632) |
<0.0001 | |
| With | ||||||
| Adjusted OR (95%CI) | 1 | 0.947 (0.639–1.403) |
1.174 (0.808–1.704) |
1.674 (1.178–2.378) |
0.0011 | |
| Diabetes | ||||||
| Without | 0.7228 | |||||
| Adjusted OR (95%CI) | 1 | 1.092 (0.816–1.462) |
1.228 (0.922–1.635) |
1.890 (1.448–2.467) |
<0.0001 | |
| With | ||||||
| Adjusted OR (95%CI) | 1 | 1.068 (0.598–1.909) |
1.628 (0.954–2.777) |
1.558 (0.917–2.648) |
0.0377 | |
| Smoking | ||||||
| Without | 0.2723 | |||||
| Adjusted OR (95%CI) | 1 | 1.352 (0.970–1.885) |
1.501 (1.079–2.088) |
2.072 (1.518–2.829) |
<0.0001 | |
| With | ||||||
| Adjusted OR (95%CI) | 1 | 0.765 (0.500–1.169) |
1.081 (0.736–1.588) |
1.435 (0.992–2.077) |
0.0113 | |
| DEATH | ||||||
| Age | ||||||
| <60 years | 0.1022 | |||||
| Adjusted OR (95%CI) | 1 | 3.292 (0.909–11.920) |
4.901 (1.419–16.919) |
8.528 (2.599–27.983) |
<0.0001 | |
| ≥60 y | ||||||
| Adjusted OR (95%CI) | 1 | 1.192 (0.845–1.682) |
1.558 (1.127–2.154) |
2.730 (2.035–3.662) |
<0.0001 | |
| Sex | ||||||
| Male | 0.9391 | |||||
| Adjusted OR (95%CI) | 1 | 1.447 (0.920–2.277) |
1.608 (1.033–2.506) |
3.513 (2.356–5.238) |
<0.0001 | |
| Female | ||||||
| Adjusted OR (95%CI) | 1 | 1.195 (0.736–1.940) |
1.986 (1.281–3.080) |
3.091 (2.062–4.633) |
<0.0001 | |
| Hypertension | ||||||
| Without | 0.2086 | |||||
| Adjusted OR (95%CI) | 1 | 1.264 (0.766–2.083) |
1.845 (1.158–2.942) |
2.741 (1.780–4.221) |
<0.0001 | |
| With | ||||||
| Adjusted OR (95%CI) | 1 | 1.420 (0.913–2.208) |
1.818 (1.197–2.762) |
3.651 (2.494–5.346) |
<0.0001 | |
| Previous stroke or transient ischemic attack | ||||||
| Without | 0.0194 | |||||
| Adjusted OR (95%CI) | 1 | 1.242 (0.828–1.864) |
1.627 (1.107–2.390) |
2.565 (1.803–3.651) |
<0.0001 | |
| With | ||||||
| Adjusted OR (95%CI) | 1 | 1.581 (0.893–2.798) |
2.269 (1.331–3.868) |
4.893 (2.996–7.992) |
<0.0001 | |
| Diabetes | ||||||
| Without | 0.4456 | |||||
| Adjusted OR(95%CI) | 1 | 1.380 (0.959–1.986) |
1.674 (1.179–2.376) |
3.253 (2.372–4.462) |
<0.0001 | |
| With | ||||||
| Adjusted OR(95%CI) | 1 | 1.246 (0.571–2.719) |
2.327 (1.158–4.677) |
3.523 (1.824–6.804) |
<0.0001 | |
| Smoking | ||||||
| Without | 0.1505 | |||||
| Adjusted OR(95%CI) | 1 | 1.661 (1.103–2.502) |
2.113 (1.428–3.128) |
3.894 (2.722–5.571) |
<0.0001 | |
| With | ||||||
| Adjusted OR(95%CI) | 1 | 0.888 (0.505–1.562) |
1.345 (0.808–2.239) |
2.421 (1.517–3.863) |
<0.0001 | |
| POOR FUNCTIONAL OUTCOMES | ||||||
| Age | ||||||
| <60 years | 0.1260 | |||||
| Adjusted OR (95%CI) | 1 | 1.100 (0.773–1.564) |
1.173 (0.830–1.657) |
1.749 (1.270–2.409) |
0.0001 | |
| ≥60 years | ||||||
| Adjusted OR (95%CI) | 1 | 1.073 (0.914–1.259) |
1.286 (1.100–1.504) |
1.497 (1.284–1.747) |
<0.0001 | |
| Sex | ||||||
| Male | 0.1519 | |||||
| Adjusted OR (95%CI) | 1 | 1.127 (0.925–1.374) |
1.339 (1.106–1.622) |
1.731 (1.436–2.088) |
<0.0001 | |
| Female | ||||||
| Adjusted OR (95%CI) | 1 | 1.082 (0.870–1.345) |
1.230 (0.990–1.528) |
1.471 (1.193–1.813) |
0.0001 | |
| Hypertension | ||||||
| Without | 0.7175 | |||||
| Adjusted OR (95%CI) | 1 | 0.979 (0.760–1.261) |
1.144 (0.892–1.468) |
1.552 (1.224–1.969) |
0.0001 | |
| With | ||||||
| Adjusted OR (95%CI) | 1 | 1.173 (0.980–1.404) |
1.371 (1.151–1.635) |
1.672 (1.408–1.985) |
<0.0001 | |
| Previous stroke or transient ischemic attack | ||||||
| Without | 0.3029 | |||||
| Adjusted OR (95%CI) | 1 | 1.034 (0.854–1.253) |
1.223 (1.014–1.475) |
1.663 (1.390–1.990) |
<0.0001 | |
| With | ||||||
| Adjusted OR(95%CI) | 1 | 1.207 (0.962–1.514) |
1.394 (1.116–1.740) |
1.571 (1.262–1.956) |
<0.0001 | |
| Diabetes | ||||||
| Without | 0.0056 | |||||
| Adjusted OR(95%CI) | 1 | 1.110 (0.939–1.312) |
1.401 (1.191–1.649) |
1.770 (1.511–2.074) |
<0.0001 | |
| With | ||||||
| Adjusted OR(95%CI) | 1 | 1.031 (0.762–1.394) |
0.949 (0.703–1.280) |
1.187 (0.889–1.584) |
0.2941 | |
| Smoking | ||||||
| Without | 0.4488 | |||||
| Adjusted OR(95%CI) | 1 | 1.172 (0.978–1.405) |
1.279 (1.067–1.533) |
1.615 (1.355–1.925) |
<0.0001 | |
| With | ||||||
| Adjusted OR(95%CI) | 1 | 0.984 (0.767–1.262) |
1.294 (1.024–1.635) |
1.618 (1.287–2.033) |
<0.0001 | |
OR, odds ratio; 95%CI, 95% confidence interval.
Adjustments included age, sex, hypertension, hyperlipidemia, diabetes, previous stroke, or transient ischemic attack, myocardial infarction, atrial fibrillation, drinking, smoking and the NIHSS score at admission.