Figure 7.

Long-term atorvastatin (Ator) treatment altered mitochondrial ultrastructure. Healthy WT mice treated with vehicle (A), atorvastatin (Ator) (B), or pravastatin (Prava) (C) for 7 mo were perfusion fixed and assessed by TEM. Ultrastructural analysis revealed altered mitochondrial size and shape and a scattered arrangement in Ator-treated hearts (B, arrow), vs. clustered mitochondria in Prava- and Vehicle-treated controls (A, C, arrows) (n = 4 hearts/group, 2 blocks analyzed, 15 areas scanned/heart block at 2900 × each). Scale bar, 2 μm.