TABLE 1.
Effects of long-term atorvastatin and pravastatin administration on cardiac gene expression
| Atorvastatin | Pravastatin | ||||
|---|---|---|---|---|---|
| Gene name | Gene symbol | Fold change P | Fold change P | ||
| Anterior gradient 2 (Xenopus laevis) | Agr2 | 0.65 | <0.008 | ||
| Slowmo homolog 1 (Drosophila) | Simo1 | 0.69 | <0.01 | ||
| Leucine-rich repeat kinase 1 | Lrrk1 | 0.69 | <0.01 | 0.58 | <0.001 |
| Nardilysin, N-arginine dibasic convertase, NRD convertase 1 | Nrd1 | 0.72 | <0.01 | ||
| GPCR, family C, group 5C | Gprc5c | 0.74 | <0.008 | ||
| Regulatory associated protein of mTOR complex1 | Rptor | 0.69 | <0.006 | ||
| Myosin, light polypeptide 7, regulatory | Myl7 | 23.17 | <0.004 | ||
| Myosin, light polypeptide 4 | Myl4 | 7.34 | <0.009 | ||
| Nebulin | Neb | 2.13 | <0.004 | ||
| Troponin T3, skeletal, fast | Tnnt3 | 1.70 | <0.009 | ||
| Erythrocyte protein band 4.1-like 4b | Epb4.1l4b | 1.54 | <0.01 | ||
Atorvastatin reduced the expression of Arg2 (0.7-fold), Simo1 (0.7-fold), Lrrk1 (0.7-fold), Nrd1 (0.7-fold), Gprc5c (0.7-fold), and Rptor (0.7-fold), but did not alter the transcriptome expression of Myl7, Myl4, Neb, Tnnt, and Epb4.1I4b. Pravastatin also reduced Lrrk1 (0.58-fold), did not alter Arg2, Simo1, Nrd1, Gprc5c, and Rptor, but increased the expression of Myl7 (23.2-fold), Myl4 (7.3-fold), Neb (2.1-fold), Tnnt3 (1.7-fold), and Epb4.1I4b (1.5-fold). The left ventricular free wall was used for RNA extraction (n = 3–5/group). To extract biologically useful information, gene lists were generated selecting candidates with an uncorrected P < 0.01. Not statistically significant where no values are indicated.