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. 2019 Nov;33(11):12668–12679. doi: 10.1096/fj.201901360R

Figure 1.

Figure 1

Sevoflurane exposure improved the outcome of murine polymicrobial abdominal sepsis. A) Chemical structure of sevoflurane, sevoflurane metabolite (HFIP), and isoflurane. B) The outcomes of polymicrobial abdominal sepsis induced by CLP surgery in WT mice with sevoflurane (2%) exposure (n = 15), with isoflurane (0.9%) exposure (n = 10) for 6 h, and without exposure (n = 15). Statistical significance was evaluated using log-rank test. **P < 0.01. C) Systolic blood pressure of mice at the time of CLP surgery and 6 h after CLP was shown in volatile anesthetic nonexposure group (n = 6), isoflurane group (n = 6), and sevoflurane group (n = 6). Statistical analysis was performed using 2-way ANOVA; n.s, not significant.