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Schematic representation of CD82 controls CpG-dependent TLR9 signaling. CD82 interacts with TLR9 in WT macrophages in response to CpG. CD82 controls the assembly of TLR9-dependent myddosome assembly and subsequent NF-κB translocation to the nucleus and TNF-α production (left). In the absence of CD82, TLR9-mediated myddosome formation is absent, resulting in reduced TNF-α secretion (right). Illustration by Nicole Wolf, MS, ©2017. Printed with permission.
